Um Ensaio Sobre o Efeito Toxicológico e Comportamental do Hexano em Não-Humanos
Exemplificando com alguns Testes Comportamentais
DOI:
https://doi.org/10.14393/PPv24n1a2020-55717Palabras clave:
Toxicologia, Toxicologia Comportamental, Hexano, Testes Neurocomportamentais, Análise do ComportamentoResumen
O n-hexano é um químico industrial relativamente comum e empregado em diversos produtos e processos industriais. A compreensão de aspectos toxicológicos é um importante fator para o manejo da higiene industrial, a fim de evitar o risco de contaminação com o solvente. Este trabalho é uma revisão de pesquisas e escritos que caracterizam os aspectos toxicocinéticos, toxicodinâmicos e a higiene industrial relacionada ao hexano. Ademais, busca descrever os efeitos do solvente sobre o comportamento de animais, e os métodos utilizados para essas avaliações. Estudos de toxicologia comportamental com animais evidenciam os prejuízos motores e neurocomportamentais advindos da contaminação crônica ou aguda pelo hexano, e no que tange ao cenário aplicado, ações de prevenção devem ser tomadas.
Descargas
Citas
Blake, B. L. (2004). Toxicology of nervous system. In E. Hodgson (Ed.), A Textbook of Modern Toxicology (3rd ed., pp. 279–297). Hoboken: John Wiley & Sons, Ltd.
Boekelheide, K. (1987). 2,5-Hexanedione alters microtubule assembly. I. Testitular atrophy, not nervous system toxicity, correlates with enhanced tubulin polymerization. Toxicology and Applied Pharmacology, 88(3), 370–382.
Brasil. NR 7 - Programa de Controle Médico de Saúde Ocupacional (2013). Presidência da República do Brasil: Ministério do Trabalho e Emprego.
Brasil. NR 15 - Atividades e operações insalubres (2014). Presidência da República do Brasil: Ministério do Trabalho e Emprego.
Brasil. NR 9 - Programa de prevenção de riscos ambientais (2014). Presidência da República do Brasil: Ministerio do Trabalho e Emprego.
Cardona, A., Marhuenda, D., Prieto, M. J., Marti, J., Periago, J. F., & Sánchez, J. M. (1996). Behaviour of urinary 2,5-hexanedione in occupational co-exposure to n-hexane and acetone. International Archives of Occupational and Environmental Health, 68(2), 88–93.
Cory-Slechta, D. A. (1989). Behavioral measures of neurotoxicity. Neurotoxicology, 10(2), 271–295.
DeCaprio, A. P. (2000). n-Hexane, metabolites, and derivatives. In P. S. Spencer, H. H. Schaumburg, & A. C. Ludolph (Eds.), Experimental and Clinical Neurotoxicology (2nd ed., pp. 633–648). New York: Oxford University Press.
Dekant, W., & Anders, M. W. (2008). Toxicology of solvents. In H. Greim & R. Snyder (Eds.), Toxicology and Risk Assessment: A Comprehensive Introduction (pp. 604–620). West Sussex: John Wiley & Sons, Ltd.
Eckert, G. P., & Müller, W. E. (2008). The nervous system. In H. Greim & R. Snyder (Eds.), Toxicology and Risk Assessment: A Comprehensive Introduction (pp. 244–264). West Sussex: John Wiley & Sons, Ltd.
Elsner, J., Fellmann, C., & Zbinden, G. (1988). Response force titration for the assessment of the neuromuscular toxicity of 2,5-Hexanedione in rats. Neurotoxicology and Teratology, 10(1), 3–13.
Ikeda, T., Katakura, Y., Kishi, R., & Miyake, H. (1993). Acute neurobehavioral effects of co-inhalation of toluene and n-hexane on schedule-controlled behavior in rats. Environmental Research, 63(1), 70–81.
Krasavage, W. J., O’Donoghue, J. L., DiVincenzo, G. D., & Terhaar, C. J. (1980). The relative neurotoxicity of methyl-n-butyl ketone, n-hexane and their metabolites. Toxicology and Applied Pharmacology, 52(3), 433–441.
Kulig, B. M., Vanwersch, R. A. P., & Wolthuis, O. L. (1985). The automated analysis of coordinated hindlimb movement in rats during acute and prolonged exposure to toxic agents. Toxicology and Applied Pharmacology, 80(1), 1–10.
Ladefoged O., Roswall K., Larsen J. J. (1994). Acetone potentiation and influence on the reversibility of 2,5-hexanedione-induced neurotoxicitystudied with behavioural and morphometic methods in rats. Pharmacology & Toxicology, 74(4-5), 294-299.
Lam, H. R., Larsen, J. J., Ladefoged, O., Moller, A., Strange, P., & Arlien-Soborg, A. (1991). Effects of 2,5-hexanedione alone and in combination with acetone on
Leite, E. M. A. (2008). Soventes orgânicos. In S. Oga, M. M. A. Camargo, & J. A. O. Batistuzzo (Eds.), Fundamentos de Toxicologia (3rd ed., pp. 275–324). São Paulo: Atheneu Editora.
Mateus, M. L., Santos, A. P. M., & Batoréu, M. C. C. (2002). Evidence of zinc protection against 2,5-hexanedione neurotoxicity: Correlation of neurobehavioral testing with biomarkers of excretion. Neurotoxicology, 23(6), 747–754.
Maurissen, J. P. J. (1995). Neurobehavioral methods for the evaluation of sensory functions. In L. W. Chang & W. Slikker Jr. (Eds.), Neurotoxicology: Approach and Methods (pp. 239–264). San Diego: Academic Press.
NIOSH - National Institute of Occupational Safety and Health. (1983). Health Hazard Evaluation Report (HETA 80-256-1386). Cincinnati, Ohio.
NIOSH - National Institute of Occupational Safety and Health. (2013). TLVs and BEIs. Cincinnati, Ohio: ACGIH.
Petrobras. (2011). Ficha de Informação de Segurança de Produto Químico (FISPQ BR 608 - Hexano). Rio de Janeiro, Rio de Janeiro.
Politis, M. J., Pellegrino, R. G., & Spencer, P. S. (1980). Ultrastructural studies of the dying-back process. V. Axonal neurofilaments accumulate at sites of 2,5-hexanedione application: Evidence for nerve fibre dysfunction in experimental hexacarbon neuropathy. Journal of Neurocytology, 9(4), 505–516.
Sanagi, S., Seki, Y., Sugimoto, K., & Hirata, M. (1980). Peripheral nervous system functions of workers exposed to n-hexane at a low level. International Archives of Occupational and Environmental Health, 47(1), 69–79.
Seeber, A. (2008). Behavioral neurotoxicology. In H. Greim & R. Snyder (Eds.), Toxicology and Risk Assessment: A Comprehensive Introduction (pp. 265–279). West Sussex: John Wiley & Sons, Ltd.
Shell, L., Rozum, M., Jortner, B. S., & Ehrich, M. (1992). Neurotoxicity of acrylamide and 2,5-Hexanedione in rats evaluated using a functional observational battery and pathological examination. Neurotoxicology and Teratology, 14(4), 273–283.
Tanger, H. J., Vanwersch, R. A. P., & Wolthuis, O. L. (1984). Automated quantitative analysis of coordinated locomotor behaviour in rats. Journal of Neuroscience Methods, 10(3), 237–245.
Weiss, B. (1983). Behavioral toxicology and environmental health science. Opportunity and challenge for psychology. The American Psychologist, 38(11), 1174–1187. Retrieved from http://psycnet.apa.org/index.cfm?fa=buy.optionToBuy&id=1984-18192-001
WHO - World Health Organization. (1991). Environmental Health Criteria 122: n-Hexane. Vammala: WHO.
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial-SemDerivações 4.0 Internacional.