Synthesis and antifungal activity of new  O-alkylamidoximes

Maria Verônica Sales Barbosa; Alana Karoline Penha Nascimento; Rodrigo Ribeiro Alves Caiana; Cosme Silva Santos; Wylly Araújo Oliveira; Paulo Henrique Menezes; Juliano Carlo Rufino Freitas

doi:10.14393/BJ-v37n0a2021-54171

Authors

Maria Verônica Sales Barbosa Universidade Federal Rural de Pernambuco https://orcid.org/0000-0002-8653-5393
Alana Karoline Penha Nascimento Universidade Federal Rural de Campina Grande https://orcid.org/0000-0002-3472-8708
Rodrigo Ribeiro Alves Caiana Universidade Federal Rural de Campina Grande https://orcid.org/0000-0002-7935-6143
Cosme Silva Santos Universidade Federal Rural de Pernambuco https://orcid.org/0000-0001-7812-9494
Wylly Araújo Oliveira Universidade Federal Rural de Campina Grande https://orcid.org/0000-0002-7784-0302
Paulo Henrique Menezes Universidade Federal de Pernambuco https://orcid.org/0000-0002-0327-6032
Juliano Carlo Rufino Freitas Universidade Federal Rural de Campina Grande https://orcid.org/0000-0003-4617-4084

DOI:

https://doi.org/10.14393/BJ-v37n0a2021-54171

Keywords:

Antifungal, Candida, O-alkylation, O-alkylamidoximes.

Abstract

The continuous prospection for molecules that may be useful in the development of new therapeutic agents is a highly relevant issue, mainly because the launch of new drugs on the market does not accompany the emergence of new resistant microorganisms. In this context, this work describes the synthesis of new O-alkylamidoximes and the evaluation of its antifungal activity. The new O-alkylamidoximes were prepared using easy synthetic protocols and tested against three Candida species using the broth microdilution method. The synthesized compounds were obtained in moderate to good yields in high purity and without any observable decomposition. All tested compounds shown moderate antifungal activity against at least one strain of Candida. Despite the moderate activity of the new compounds, this was the first report involving the antifungal activity of O-alkylamidoximes. In view of the low chemotherapy arsenal and the development of fungal strains resistant to traditional antifungal agents, the present study opens new possibilities for the preparation of a new class of more active antifungal agents.

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