Assessment of carvacrol paste as endodontic medication associated with laser photobiomodulation in tissue repair: an experimental study in rats

Authors

  • Ismário Silva Meneses Universidade Federal de Sergipe
  • Ricardo Luiz Cavalcanti de Albuquerque Júnior Universidade Tiradentes
  • Felipe de Souza Matos Universidade Federal de Uberlândia
  • Aline Aragão Pereira Macedo Universidade Federal de Sergipe
  • Adriano Antunes de Souza Araújo Universidade Federal de Sergipe
  • Talita Dionízio Santos Universidade Federal de Sergipe
  • Nayara Santos Souza Universidade Federal de Sergipe
  • Luiz Renato Paranhos Universidade Federal de Uberlândia
  • Lucindo José Quintans-Júnior Universidade Federal de Sergipe
  • Maria Amália Gonzaga Ribeiro Universidade Federal de Sergipe

DOI:

https://doi.org/10.14393/BJ-v36n5a2020-50349

Keywords:

Biocompatible materials, Carvacrol., Endodontics, Laser therapy, Wound healing.

Abstract

This study aimed to analyze the tissue reaction caused by carvacrol paste associated or not with laser photobiomodulation (LPBM) at λ660 nm in the subcutaneous tissue of rats. Sixty Wistar rats were divided into four groups and they received the following interventions: subcutaneous implantation of empty polyethylene tubes (CTR), implantation of tubes containing carvacrol paste (CVC), implantation of empty tubes and LPBM (LLLT), and implantation of tubes containing carvacrol paste and LPBM (CVCLT). The animals were euthanized at three, eight, and 15 days after surgery. The inflammatory reaction and fibroplasia were analyzed histomorphometrically. Significant differences among the groups were determined by ANOVA and Tukey's test (p<0.05). In the 3-day period, the CVCLT group had low inflammatory infiltration (p<0.01). In the 8- and 15-day periods, the LLLT and CVCLT groups presented a low amount of lymphocytic inflammatory infiltrate (p<0.01 and p<0.05). Regarding the formation of fibrous tissue, the CVC group had the highest formation of type III collagen in the 8-day period (p<0.001). In the 15-day period, the CVCLT group had a lower formation of type I collagen than the CTR and LLLT groups (p<0.05). The use of the carvacrol paste associated with photobiomodulation optimizes the inflammatory period and tissue repair.

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Published

2020-08-13

How to Cite

ISMÁRIO SILVA MENESES, RICARDO LUIZ CAVALCANTI DE ALBUQUERQUE JÚNIOR, MATOS, F. de S., ALINE ARAGÃO PEREIRA MACEDO, ADRIANO ANTUNES DE SOUZA ARAÚJO, SANTOS, T.D.., NAYARA SANTOS SOUZA, LUIZ RENATO PARANHOS, LUCINDO JOSÉ QUINTANS-JÚNIOR and MARIA AMÁLIA GONZAGA RIBEIRO, 2020. Assessment of carvacrol paste as endodontic medication associated with laser photobiomodulation in tissue repair: an experimental study in rats. Bioscience Journal [online], vol. 36, no. 5, pp. 1794–1805. [Accessed8 December 2022]. DOI 10.14393/BJ-v36n5a2020-50349. Available from: https://seer.ufu.br/index.php/biosciencejournal/article/view/50349.

Issue

Section

Health Sciences