Acetylcholinesterase and α-Amylase inhibitors from Mouriri elliptica Martius leaf extract

Authors

  • Letícia Siqueira da Silva Instituto Federal Goiano
  • Cinthia Alves Porfiro Instituto Federal Goiano
  • Fabiano Guimarães Silva Instituto Federal Goiano
  • Agna Rita dos Santos Rodrigues Instituto Federal Goiano
  • Paulo Sérgio Pereira Instituto Federal Goiano

DOI:

https://doi.org/10.14393/BJ-v36n2a2020-42714

Keywords:

Cerrado, enzymatic inhibition, botanical pesticides, chromatography

Abstract

Population growth has raised food production, and new sources are needed to increase quantity and quality of agricultural products. Carbamates and organophosphates are insecticide classes used worldwide as acetylcholinesterase (AChE) inhibitors. Plants have a natural resistance to insects, which can be employed in pest control as a new alternative to reduce the use of chemicals. An alternative may be the use of α-amylase inhibitors, which are digestive enzymes that impair pest species growth and development. Another would be acetylcholinesterase inhibitors since they damage the normal functioning of the central and peripheral nervous system, by releasing high concentrations of acetylcholine in cholinergic synapses. This substance accumulation increases stimulations that lead to behavioral changes, asphyxia, hyperactivity, and death. Botanical agrochemicals are believed to have advantages over synthetic ones, as they are rapidly degraded in the environment. In this scenario, plants have played an important role in pest control as sources of interest for the synthesis of new molecules for agricultural use. The present study evaluated acetylcholinesterase and α-amylase inhibition by microplate method, from leaf extracts of Mouriri elliptica Martius with different polarities.

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Published

2020-02-11

How to Cite

SILVA, L.S. da, PORFIRO, C.A., SILVA, F.G., RODRIGUES, A.R. dos S. and PEREIRA, P.S., 2020. Acetylcholinesterase and α-Amylase inhibitors from Mouriri elliptica Martius leaf extract. Bioscience Journal [online], vol. 36, no. 2, pp. 578–590. [Accessed7 December 2022]. DOI 10.14393/BJ-v36n2a2020-42714. Available from: https://seer.ufu.br/index.php/biosciencejournal/article/view/42714.

Issue

Section

Biological Sciences