Olive oil: research model to clarify its health benefits and its unique mechanism of action
DOI:
https://doi.org/10.14393/BJ-v40n0a2024-72599Keywords:
Cardiac tissue Chromosomal aberration Cytokines Lipid profile, Olive oil, γ-Radiation.Abstract
The uniqueness of Extra Virgin Olive Oil (EVOO) convincing evidence that its intake has many health aspects by increased longevity and prevention of many age-associated non infectious diseases such as cardiovascular and neurodegenerative diseases. In this study, Twenty-four rats were divided into 4 groups (6 rats each), as a following: Control group, EVOO group: rats were oral administrated with EVOO at a dose of 1ml/100g body weight for two weeks, Irradiated group (IR): rats were exposed to 6Gy of whole body γ-radiation; EVOO and IR group: rats were oral administrated with EVOO for two weeks prior to irradiation (6Gy). EVOO successfully reduces cellular destruction, chromosomal aberrations, pro-inflammatory markers interleukin-1β (IL-1β),and ameliorates heart and coronary arteries tissues damages, accompanied by lowering Vascular Endothelial Growth Factor (VEGF),Total Cholesterol (TC) and Triglyceride levels (TG). Therefore, EVOO provided adequate protection for cells against exposure to harmful ionizing irradiation (6 Gy).
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ACEVEDO, N., et al. Histone acetylation of immune regulatory genes in human placenta in association with maternal intake of olive oil and fish consumption. International Journal Molecular Science. 2019, 20(5), 1060. https://doi.org/10.3390/ijms20051060
AHMED, M.M., et al. Another Concept of Cancer Interpretation in View of the Interaction between Plasma Radiation and DNA. Clinical Cancer Investigation Journal. 2022,11(4), 33-43. https://doi.org/10.51847/Pms16qq3BK
AHMED, M.M., et al. Radioprotective role of α-tocotrienol against oxidative damage in γ-irradiated human blood cultures. Bioscience Journal. 2018, 34(2), 400–409.
ALLAIN, C.C., et al. Enzymatic determination of total serum cholesterol.ClinIcal Chemistry. 1974, 20(4), 470-475. PMID: 4818200.
ASMAA, A.S. and AMEL, F.M.I. Protective impact of Spirulinaplatensis against γ-irradiation and thioacetamide-induced nephrotoxicity in rats mediated by regulation of micro-RNA 1 and micro-RNA 146a, Toxicology Research. 2021, 10(3), 453–466. https://doi.org/10.1093/toxres/tfab037
BALLARINI, F. and CARANTE, M. Chromosome aberrations and cell death by ionizing radiation: Evolution of a biophysical model. Radiation Physics and Chemistry. 2016, 128, 18-25. https://doi.org/10.1016/j.radphyschem.2016.06.009
CALABRISON, MASSARO, M., et al. Extra virgin olive oil rich in polyphenols modulates VEGF-induced angiogenic responses by preventing NADPH oxidase activity and expression. The Journal of nutritional biochemistry. 2016, 28: 19-29. https://doi.org/10.1016/j.jnutbio.2015.09.026
CARULLO, G., et al. Mantonico and pecorello grape seed extracts: Chemical characterization and evaluation of in vitro wound-healing and anti-inflammatory activities. Pharmaceuticals. 2020, 13, 97. https://doi.org/10.3390/ph13050097
CASADESÚS, J. and NOYER-WEIDNER, M., Epigenetics. Brenner’s Encyclopedia of Genetics. 2nd Ed. San Diego: Academic Press; 2013.
CASADO-DÍAZ, A., DORADO, G., and QUESADA-GÓMEZ, J.M. Influence of olive oil and its components on mesenchymal stem cell biology. World Journal of Stem Cells 2019, 11(12), 1045-1064. https://doi.org/10.4252/wjsc. v11.i12.1045
CELANO, R., et al. Insights into the Analysis of Phenolic Secoiridoids in Extra Virgin Olive Oil. Journal of Agricultur and Food Chemmisrty. 2018, 66, 6053–6063.https://doi.org/10.1021/acs.jafc.8b01751
CHANG, G.L., et al. Mast cell degranulation and vascular endothelial growth factor expression in mouse skin following ionizing irradiation. Journal of Radiation Research 2021, 62(5), 856–860. https://doi.org/10.1093/jrr/rrab067
D’ALESSANDRO, A. and DE PERGOLA, G. Mediterranean Diet and Cardiovascular Disease: A Critical Evaluation of a Priori Dietary Indexes. Nutrients. 2015, 7, 7863–7888. https://doi.org/10.3390/nu7095367
DARWISH, I.A.E. and MOSALLAM, S.A.E. Chromosome aberrations in bone marrow cells of rats treated with MTBE. Pakistan journal of pharmaceutical sciences. 2019, 32(1), 89–93. PMID: 30772795.
DE SANTIS, S., CLODOVEOM, L., and CORBO, F. Correlation between chemical characterization and biological activity: An urgent need for human studies using Extra Virgin Olive Oil. Antioxidants. 2022, 11(2), p.258. https://doi.org/10.3390/antiox11020258
DE SANTIS, S., et al. Extra virgin olive oil extracts modulate the inflammatory ability of murine dendritic cells based on their polyphenols pattern: Correlation between chemical composition and biological function. Antioxidants 2021, 10, (7),1016. https://doi.org/10.3390/antiox10071016
DEL SAZ-LARA, A., et al. Nutri-Epigenetic Effects of Phenolic Compounds from Extra Virgin Olive Oil: A Systematic Review. Advances in nutrition. 2022, 13(5), 2039–2060. https://doi.org/10.1093/advances/nmac067
EL-DEEB, A.E., ABD EL-ALEEM, I.M., Abd EL-RAHAMAN,A.A. The curative effect of some antioxidants on γ-irradiated rats. Journal of the Egyptian Society of Toxicology. 2006, 35: 79-89.
FABIANI, R., et al. Oxidative DNA damage is prevented by extracts of olive oil, hydroxytyrosol, and other olive phenolic compounds in human blood mononuclear cells and HL60 cells. Journal of Nurtition. 2008, 138, 1411-1416. https://doi.org/10.1093/jn/138.8.1411
FARAHAT, A. A., SAWIRESS, F. A., and AGHWIDER, A. A. Effect of Virgin Olive Oil Supplementation on Some Hematologic and Thyroid Hormones, Levels in Rats. Journal of Veterinary Medical Research. 2019, 26 (1), 41-47. https://doi.org/10.21608/jvmr.43332
FOSCOLOU, A., CRITSELIS, E., and PANAGIOTAKOS, D. Olive oil consumption and human health: A narrative review. Maturitas. 2018, 118, 60–66. https://doi.org/10.1016/j.maturitas.2018.10.013
FOSSATI, P., and PRENCIPE, L. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clinical Chemistry. 1982, 28(10),2077-2080. https://doi.org/10.1093/clinchem/28.10.2077
GOYES, J.C.R., et al. Biologic effect of ionizing radiation. InterventionalCardiology. 2018,10(6), 133–138.
JIMENEZ-LOPEZ, C., et al. Bioactive compounds and quality of extra virgin olive oil. Foods. 2020, 9(8),1014. https://doi.org/10.3390/foods9081014
KALEKHAN, F., et al. Traditionally Used Natural Products in Preventing Ionizing Radiation-Induced. Medicinal Chemistry-Anti-Cancer Agents. 2022, 22(1), 64-82. https://doi.org/10.2174/1871520621666210405093236
KIM, E. J., et al. Ionizing Radiation regulates vascular endothelial growth factor-A transcription in cultured human vascular endothelial cells via the PERK/eIF2α/ATF4 pathway. International Journal of Radiation Oncology and *Biology* Physics. 2020, 107(3), 563-570. https://doi.org/016/j.ijrobp.2020.03.003
KOUKOURAKIS, M.I. Radiation damage and radioprotectants: new concepts in the era of molecular medicine. The British Journal of Radiology. 2012, 85(1012), 313–330. https://doi.org/10.1259/bjr/16386034
KYRIAKIDIS, N.B., and SKARKALIS, P. Fluorescence spectra measurement of olive oil and other vegetable oils. Journal of AOAC International. 2000, 83(6), 1435-1439. https://doi.org/10.1093/jaoac/83.6.1435
LAMY, S., et al. Olive oil compounds inhibit vascular endothelial growth factor receptor-2 phosphorylation. Experimental cell research. 2014, 322(1), 89–98. https://doi.org/10.1016/j.yexcr.2013.11.022
LAZIC, S.E. Why we should use simpler models if the data allow this: relevance for ANOVA designs in experimental biology. BMC Physiology. 2008, 8, 16. https://doi.org/10.1186/1472-6793-8-16
LI, W., et al. Blocking the function of inflammatory cytokine s an d mediator s b y usin g IL -10 and TGF-β: A potential biological immunotherapy for interverte-bral disc degeneration in a beagle model. International Journal of Molecular Science. 2014,15,17270-17283. https://doi.org/10.3390/ijms151017270
MANSOUR, H.H. Protective effect of ginseng against gamma-irradiation –induced oxidative stress and endothelial dysfunction in rats. EXCLI journal. 2013, 12, 766-777.
MARTIN-PELAEZ, S., et al. Effect of virgin olive oil and thyme phenolic compounds on blood lipid profile: Implications of human gut microbiota. European journal of nutrition. 2017,56,119–31. https://doi.org/10.1007/s00394-015-1063-2
MONTASER, S.A., AHMED, M.M., and IBRAHIM, S.I. Antioxidant Capacity of Achilleamillefolium L. against Cytogenetic and Immunological Disorders in Irradiated Human Blood Cultures. Egyptian Journal of Radiation Science and Applications .2019, 32, (2): 137-144. https://doi.org/10.21608/ejrsa.2019.14648.1077
NWOKOCHA, C.R., et al. Serum lipids, proteins and electrolyte profiles in rats following total body irradiation. The West Indian medical journal. 2012, 61(2), 117–121. PMID: 23155954
PEDRET, A., et al. Cardiovascular benefits of phenol-enriched virgin olive oils: New insights from the Virgin Olive Oil and HDL functionality (VOHF) study. Molecular nutrition & food research. 2018, 62(16), 1800456. https://doi.org/10.1002/mnfr.201800456
RIETJENS, S.J., et al. The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress-induced impairment of the NO • response of isolated rat aorta. American Journal of Physiology-Heart and Circulatory Physiology. 2007, 292(4), H1931-6. https://doi.org/10.1152/ajpheart.00755.2006
SCHWINGSHACK, L.L., MORZE, J., and HOffMANN, G. Mediterranean diet and health status: Active ingredients and pharmacological mechanisms. British Journal of Pharmacology. 2020, 177, 1241–1257. https://doi.org/10.1111/bph.14778
SHANNON, O.M., et al. Mediterranean diet and the hallmarks of ageing. European Journal Clinical Nutrition. 2021, 75, 1176–1192. https://doi.org/10.1038/s41430-020-00841-x
SHMARINA, G.V., et al. Tumor necrosis factor-a/interleukin-10 balance in normal and cystic fibrosis children. Mediators of Inflammation. 2001, 10, 191–197. https://doi.org/10.1080/09629350123387
SIDDEEK, B., and SIMEONI, U. Epigenetics provides a bridge between early nutrition and long-term health and a target for disease prevention. Acta Paediatrica. 2022, 111, 927–34. https://doi.org/10.1111/apa.16258
SMITH, A.N., et al. Unsaturated fatty acids induce mesenchymal stem cells to increase secretion of angiogenic mediators. Journal of Cell Physiology. 2012, 227, 3225-3233. https://doi.org/10.1002/jcp.24013
SUVARNA, S.K., CHRISTOPHER, L., and JOHN, D. B. "Theory and practice of histological techniques." Pbl London, Churchill Livingstone, Elsiver 2013, 173-187.
TAN, F.C., et al. Protective effect of pycnogenol against gamma radiation-induced lung injury in rat: DNA damage, lipid peroxidation, antioxidant levels, and histopathological changes. Journal of cancer research and therapeutics. 2022, 18(6), 1658-1665. https://doi.org/10.4103/jcrt.JCRT_1062_20
VANDERSTRAETEN, J., et al. Modulation of VEGF Expression and Oxidative Stress Response by Iodine Deficiency in Irradiated Cancerous and Non-Cancerous Breast Cells. International journal of molecular sciences. 2020, 21(11), 3963. https://doi.org/10.3390/ijms21113963
VENTURINIA, F., et al. Physico-chemical properties extraction from the fluorescence spectrum with 1D-convolutional neural networks: application to olive oil. arXiv preprint arXiv. 2022, 2203.07229. https://doi.org/10.48550/arXiv.2203.07229
ZRELLI, H., et al. Hydroxytyrosol reduces intracellular reactive oxygen species levels in vascular endothelial cells by upregulating catalase expression through the AMPK-FOXO3a pathway. European Journal Pharmacology. 2011, 660, 275–282. https://doi.org/10.1016/j.ejphar.2011.03.045
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Copyright (c) 2024 Ahmad Rashad Kassem, Mahmoud Mohamed Ahmed, Sherien Abdelwahab Montaser, Zeinab Salem Said Hassan, Manal Ramadan Mohammed
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