Antibacterial activity of Mangifera indica seed extracts combined with common antibiotics against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii isolates

Shadi Zeraatkar; Maedeh Tahan; Omefarveh Rostami; Alireza Neshani; Hadi Farsiani; Arezou Shahsavari; Hadi Safdari; Mahdi Hosseini Bafghi

doi:10.14393/BJ-v39n0a2023-66760

Authors

Shadi Zeraatkar Mashhad University of Medical Sciences https://orcid.org/0000-0002-3730-9533
Maedeh Tahan Mashhad University of Medical Sciences https://orcid.org/0000-0002-2691-8157
Omefarveh Rostami Mashhad University of Medical Sciences https://orcid.org/0000-0001-5644-4311
Alireza Neshani Mashhad University of Medical Sciences https://orcid.org/0000-0001-8645-4916
Hadi Farsiani Mashhad University of Medical Sciences
Arezou Shahsavari Mashhad University of Medical Sciences
Hadi Safdari Mashhad University of Medical Sciences
Mahdi Hosseini Bafghi Mashhad University of Medical Sciences https://orcid.org/0000-0003-3632-3170

DOI:

https://doi.org/10.14393/BJ-v39n0a2023-66760

Keywords:

Acinetobacter baumannii, Antimicrobial activity, Mangifera indica, Multidrug resistance, Pseudomonas aeruginosa.

Abstract

In this project, we employed ethanolic (EMI) and aqueous (AMI) extracts of mango (Mangifera indica L., Anacardiaceae) fruit seeds as a modulator of antibiotic resistance against multidrug-resistant (MDR) Pseudomonas aeruginosa and Acinetobacter baumannii to evaluate natural compounds isolated from by-products or waste of edible plants. We also investigated the effect of these extracts alone and in combination with standard classes of antibiotics in the desired strains. M. indica seeds were processed and exploited using ethanol and water. The minimum inhibitory concentrations (MICs) of clinical isolates were examined against EMI and AMI extracts, followed by seven antibiotics of ceftazidime, ciprofloxacin, penicillin, amikacin, meropenem, ampicillin, and colistin. The checkerboard method evaluated the synergistic action between mango kernel extract (EMI) and seven antibiotics. EMI extract significantly revealed antimicrobial properties against MDR A. baumannii and P. aeruginosa with synergistic effects with the applied antibiotics. The considerable antibacterial efficacy of ethanolic extract of M. indica seeds can have great curative value as antibacterial drugs against infections caused by MDR P.aeruginosa and A. baumannii.

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