Anti-fasciolic effect of raw seeds of Nigella sativa, Fumaria parviflora (aerial), in naturally infected Buffaloes
DOI:
https://doi.org/10.14393/BJ-v39n0a2023-65038Keywords:
Buffaloes, Comparative Efficacy, Fasciolosis, Medicinal Plants.Abstract
In the present study Nigella sativa (seeds) and Fumaria parviflora (aerial), were used to treat buffaloes naturally infected with fasciolosis and their efficacy (%) was compared. In vivo, pre-and post-treatment (50 mg, 100 mg, and 150 mg/ kg body weight of the two medicinal plants) fecal egg counts were determined following standard fecal egg count reduction in buffaloes (Babulus sp.) of Nili Ravi breed naturally parasitized with Fasciola sp. The infected buffaloes were randomly divided into 3 main groups’ i.e. A, B, and C. Animals in groups A and B were further subdivided into three subgroups i.e. A1, A2, A3; B1, B2, B3. Sub-groups A1 and B1 were given dose levels of 50mg/kg body weight, A2, and B2, 100mg while A3 and B3, 150mg/kg body weight of Nigella sativa (seeds) and Fumaria parviflora (aerial), respectively. Group C with infected animals served as a control. 2 medicinal plants has been found significantly (P<0.05) efficient (42-100%) and safe to use against fasciolosis.
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AKHTAR, M., et al. Anthelmintic activity of medicinal plants with particular reference to their use in animals in the Indo–Pakistan subcontinent. Small Ruminant Research. 2000, 38, 99-107. https://doi.org/10.1016/S0921-4488(00)00163-2
AKHTAR, M.S. and FARAH, N. Phytochemical screening of Morus alba (stem bark), Nigella sativa (seed) and Fumaria parviflora (aerial parts). Pakistan Journal of Pharmaceutical Sciences. 1986, 5, 9-14.
AKHTAR, M.S. and JAVED, I. Efficacy of Nigella sativa Linn seeds against Moniezia infection in sheep. Indian Veterinary Journal. 1991, 68, 726–729.
AKHTAR, M.S. and ASLAM, M. Field trial of Karanjwa seeds against nematodes in sheep. Pakistan Journal of Agricultural Research. 1989, 10, 175–178.
AKHTAR, M.S. and ASLAM, M. Anticestodal principles of Nigella sativa, Linn. (Kalonji) seeds. Pakistan Journal of Pharmacology. 1997, 4, 7–14.
AKHTAR, M.S. and HASSAN, I. J. Evaluation of Saussurea lappa roots (Qust) against natural infection of gastrointestinal nematodes in sheep. Pakistan Journal of Agricultural Research. 1985, 22, 1–7.
AKBARY, S.M., et al., The effect of different levels of Lam. on the Fumaria parviflora functions and death rates of fleshy chickens under heat stress conditions. Journal of Food, Agriculture & Environment. 2011, 9(3&4), 605-607.
AKHTAR, M.S. and JAVED, I. Comparative efficacy of Fumaria parviflora and morantel tartrate against gastrointestinal nematode infection in sheep. Pakistan Journal of Pharmacology. 1985, 2, 31–35.
AKHTAR, M.S. and MAKHDOOM, S. Antinematodal efficacy of glycosides isolated from Saussurea lappa (Qust or Kooth) in sheep and buffalo calves. Pakistan Journal of Pharmacology. 1988, 5, 59–64.
ASSAYED, M.E. Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats. Immunopharmacology & Immunotoxicology. 2010, 32(2), 284–296. https://doi.org/10.3109/08923970903307552
ABEL-SALAM, B.K. Immunomodulatory effects of black seeds and garlic on alloxan-induced diabetes in albino rat. Allergologia et Immunopathologia. 2012, 40(6), 336–340. https://doi.org/10.1016/j.aller.2011.07.002
ABDEL-ZAHER, A.O., ABDEL-RAHMAN M.S. and ELWASEI F.M. Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: role of nitric oxide and oxidative stress. Neurotoxicology. 2011, 32(6), 725–733. https://doi.org/10.1016/j.neuro.2011.08.001
BOSKABADY, M.H., MOHSENPOOR, N. and TAKALOO, L. Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine. 2010, 17(10), 707–713. https://doi.org/10.1016/j.phymed.2010.01.002
BARDUAGNI, P., et al. Use of triclabendazole for treatment of patients co-infected by Fasciola spp. and Schistosoma mansoni in Behera Governorate, Egypt. Parasitology Research. 2008, 102, 631-633. https://doi.org/10.1007/s00436-007-0802-6
COSME, A., et al. Fasciola hepatica. Study of a series of 37 patients. European Journal of Gastroenterology & Hepatology. 2001, 24, 375-380. https://doi.org/10.1016/s0210-5705(01)70204-x
CURTALE, F. Treatment of human fasciolosis with triclabendazole: good news. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2008, 102, 508. https://doi.org/10.1016/j.trstmh.2008.02.002
DABA, M.H. and ABDEL-REHMAN, M.S. Heptoprotective activity of thymoquine in isolated rat hepatocytes. Journal de Pharmacie de Belgique. 1998, 53, 87-93. https://doi.org/10.1016/s0378-4274(98)00012-5
DAUCHY, F., et al. Fascioliasis: a 23-year retrospective study. La Presse Médicale. 2007, 36, 1545-1549. https://doi.org/10.1016/j.lpm.2007.02.039
ESTEBAN, J.G., BARGUES, M.D. and MAS-COMA, S. Geographical distribution, diagnosis and treatment of human fascioliasis: a review. Parasitology Research. 1998, 58, 13-48.
FARID, Z., et al. Unsuccessful use of paraziquantel to treat acute fasciolosis in children. Journal of Infectious Diseases. 1986, 154, 920-921. https://doi.org/10.1093/infdis/154.5.920
GAASENBEEK, C., et al. An experimental study on triclabendazole resistance of Fasciola hepatica in sheep. Veterinary Parasitology. 2001, 95, 37–43. https://doi.org/10.1016/S0304-4017(00)00413-1
GENDY, E., et al. Evaluation of the possible antioxidant effects of Soybean and Nigella sativa during experimental hepatocarcinogenesis by nitrosamine precursors. Turkish Journal of Biochemistry. 2007, 32(1), 5–11.
GHAZANVI, K. Tibb-i-Nabvavi (Peace be upon him) our Jadeed Science. (Urdu). Faisal Publishers Urdu Bazar, Lahore. 1988, 1, 228-232.
GIORGI, M., et al. Pharmacokinetics and microsomal oxidation of praziquantel and its effects on the P450 system in three-month-old lambs infested by Fasciola hepatica. Journal of Veterinary Pharmacology and Therapeutics. 2001, 24, 251-259. https://doi.org/10.1046/j.1365-2885.2001.00341.x
IBARRA-VELARDE, F., et al. Efficacy of combined chemotherapy against gastrointestinal nematodes and Fasciola hepatica in cattle. Veterinary Parasitology2001, 99, 199-204. https://doi.org/10.1016/s0304-4017(01)00460-5
JABBAR, A., et al., Anthelmintic activity of Chenopodium album (L.) and Caesalpinia crista (L.) against trichostrongylid nematodes of sheep. Journal of Ethnopharmacology. 2007, 114, 86-91. https://doi.org/10.1016/j.jep.2007.07.027
JHANGIR, M. et al. Therapy of Ancylostomasis in dogs with Nigella sativa (Khalongi) and Saussurea lappa (Qust-e-shireen). Haryana Vet J Ind. 2003, 40, 48-51.
KAILANI, S.R., AKHTAR, M.S. and ASHRAF, M. Antifasciolic efficacy of indigenous plant drugs: kalonji, shahterah and karanjwa in buffaloes. Pakistan Journal of Pharmaceutical Sciences. 1995, 8, 17-27.
KEISER, J., et al. Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2007, 101, 1219-1222. https://doi.org/10.1016/j.trstmh.2007.07.012
KHALED, A.A.S. Gastroprotective effects of Nigella Sativa oil on the formation of stress gastritis in hypothyroidal rats. International Journal of Physiology, Pathophysiology and Pharmacology. 2009, 1, 143–149.
KOKO, W.S., GALAL, M. and KHALID, H.S. Fasciolicidal efficacy of Albizia anthelmintica and Balanites aegyptiaca compared with albendazole. Journal of Ethnopharmacology. 2000, 71, 247-252. https://doi.org/10.1016/s0378-8741(00)00172-0
LANE, G. Anthelminthic resistance. Veterinary Records. 1998, 143, 332.
LOPEZ-VELEZ, R., DOMINGUEZ-CASTELLANO, A. and GARRON, C. Successful treatment of human fasciolosis with triclabendazole. European Journal of Clinical Microbiology & Infectious Diseases. 1999, 18, 525-526.
MAQBOOL, A., AMIN, M.K. and HUSSAIN, S. Comparative efficacy of different injectable fasciolicides against fasciolosis in buffaloes. Journal of Animal and Plant Sciences. 1992, 2, 24. https://doi.org/10.1016/j.vetpar.2005.10.008
MAQBOOL, A., AMIN, M. K. and BUTT, A. A. Fasciolicidal action of Nitroxynil, Niclofolan and Refoxanide against fasciolosis in buffaloes. Indian Journal of Veterinary Medicine. 1996, 20, 222-224.
MAQBOOL, A., et al. Epidemiology and chemotherapy of fascioliasis in buffaloes. Assiut Veterinary Medical Journal. 1994, 30, 115-123.
MAQBOOL, A., HAYAT, C. S. and TANVEER, A. Comparitive efficacy of various indigenous and allopathic drugs against fasciolosis in buffaloes. Veterinary Arhives. 2004, 2004, 107-114.
MAS-COMA, S., BARGUES, M.D. and ESTEBAN, J. G. Human Fasciolosis. In: Dalton, J.P. (Ed.), Fasciolosis. CAB International Publishing, Wallingford, Oxon, UK. 1999, 411–434.
MASSOUD, A., et al. Preliminary study of therapeutic efficacy of a new fasciolicidal drug derived from Commiphora molmol (myrrh). American Journal of Tropical Medicine and Hygiene. 2001, 65, 96-99. https://doi.org/10.4269/ajtmh.2001.65.96
MILLAN, J.C., et al., The efficacy and tolerability of triclabendazole in Cuban patients with latent and chronic Fasciola hepatica infection. American Journal of Tropical Medicine and Hygieneg. 2000, 63, 264-269. https://doi.org/10.4269/ajtmh.2000.63.264
MITCHELL, G.B., MARIS, L. and BONNIWELL, M.A. Triclabendazole-resistant liver fluke in Scottish sheep. Veterinary Record. 1998, 143, 399.
MOLL, L., et al. Resistance of Fasciola hepatica against triclabendazole in cattle and sheep in the Netherlands. Veterinary Parasitology. 2000, 91, 153-158. https://doi.org/10.1016/S0304-4017(00)00267-3
MOSKEY, H.E. and HARWOOD, P.D. Methods evaluating the efficacy of anthelmintics. American Journal of Veterinary Research. 1941, 2, 55-59.
MODI, K., AMIN, A. and SHAH, M.A. Pharmacognostical study on Fumaria parviflora Lam. Journal of Natural Remedies. 2016, 16, 1–6. https://doi.org/10.18311/jnr/2016/748
NATH, V.T. Ayurvedic Jari Bootian (Urdu). Idarahe Matboati Sulemani, Urdu, Bazar Lahore, (1983), 523-530.
NAZ, I., et al. In vitro and in planta nematicidal activity of Fumaria parviflora (Fumariaceae) against the southern root-knot nematode Meloidogyne incognita. Plant Pathology. 2013, 62, 943–952. https://doi.org/10.1111/j.1365-3059.2012.02682.x
ORTIZ, P., et al. Human fascioliasis: prevalence and treatment in a rural area of Peru. Reviews of Infectious Disease. 2000, 2, 42-46.
OVEREND, D.J. and BOWEN, F.L. Resistance of Fasciola hepatica to triclabendazole. Australian Veterinary Journal. 1995, 72, 275–276. https://doi.org/10.1111/j.1751-0813.1995.tb03546.x
SALVIOLI, L., CHITSULO, L. and MONTRESOR, A. New opportunities for the control of fasciolosis. Planning and technical guidance, communicable diseases prevention and control, WHO, Geneva. Bulletin of the Société de Pathologie Exotique. 1999, 3, 471–474.
SANCHEZ-ANDRADE, R., et al. Effect of fasciolicides on the antigenaemia in sheep naturally infected with Fasciola hepatica. Parasitology Research. 2001, 87, 609-614. https://doi.org/10.1007/s004360100425
SOULSBY, E.E. Helminths, arthropods and protozoa of domesticated animals. 7th Ed ELBS Bailliere Tindall and Cassel, London. 1982, 787-792.
TALAIE, H., et al. Randomized trial of a single, double and triple dose of 10 mg/kg of a human formulation of triclabendazole in patients with fascioliasis. Clinical and Experimental Pharmacology and Physiology. 2004, 31, 777–782. https://doi.org/10.1111/j.1440-1681.2004.04093.x
TAWFEEK, G.M. and HUSSEIN, D.A. IgM and IgG cystatin capture enzyme linked immunosorbent assays: a tool for serodiagnosis and assessment of cure of acute fascioliasis after triclabendazole (TCZ; Fasinex) therapy. Journal of the Egyptian Society of Parasitology. 2000, 30, 679-697.
VAN DAELE, P.L., MADRETSMA, G.S. and VAN AGTMAEL, M.A. Stomachache and fever after consumption of watercress in Turkey: fascioliasis. Nederlands Tijdschrift voor Geneeskunde. 2001, 145, 1896-1899.
YARNELL, E. and ABASCAL, K. Nigella sativa: holy herb of the middle East. Alternative and Complementary Therapies. 2011, 17(2), 99–105. http://dx.doi.org/10.1089/act.2011.17203
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