Potential of Tetradenia riparia leaf essential oil and its fractions in controlling Aedes aegypti and Rhipicephalus microplus larvae

Letícia Ferarrese; Herika Line Marko de Oliveira; Gabriella Santana de Oliveira; Juliana Aparecida Mendonça; Wilsandrei Cella; Mário de Luca Neto; Rodrigo Sadao Inumaro; Larissa Rafaela de Paula Ferreira; Heris Lorenzi dos Santos Perfeito; Ezilda  Jacomassi; José Eduardo Gonçalves; Ranulfo Piau Junior; Daniela Dib Gonçalves; Carla Maria Mariano Fernandez; Zilda Cristiani Gazim

doi:10.14393/BJ-v39n0a2023-63187

Authors

Letícia Ferarrese Universidade Paranaense https://orcid.org/0000-0002-3167-4062
Herika Line Marko de Oliveira Universidade Paranaense https://orcid.org/0000-0003-3446-9408
Gabriella Santana de Oliveira Universidade Paranaense https://orcid.org/0000-0003-0637-3898
Juliana Aparecida Mendonça Universidade Paranaense https://orcid.org/0000-0002-5818-4186
Wilsandrei Cella Universidade Paranaense https://orcid.org/0000-0002-8107-3062
Mário de Luca Neto Universidade Paranaense https://orcid.org/0000-0002-2134-8191
Rodrigo Sadao Inumaro Universidade Cesumar https://orcid.org/0000-0003-1662-6748
Larissa Rafaela de Paula Ferreira Universidade Paranaense https://orcid.org/0000-0002-8087-8555
Heris Lorenzi dos Santos Perfeito Universidade Paranaense https://orcid.org/0000-0003-4904-6096
Ezilda Jacomassi Universidade Paranaense https://orcid.org/0000-0003-0967-8427
José Eduardo Gonçalves Universidade Cesumar https://orcid.org/0000-0002-2505-0536
Ranulfo Piau Junior Universidade Paranaense https://orcid.org/0000-0003-4765-6544
Daniela Dib Gonçalves Universidade Paranaense https://orcid.org/0000-0001-8322-8905
Carla Maria Mariano Fernandez Universidade Paranaense https://orcid.org/0000-0001-7324-5533
Zilda Cristiani Gazim Universidade Paranaense

DOI:

https://doi.org/10.14393/BJ-v39n0a2023-63187

Keywords:

Acetylcholinesterase, Cattle tick, Dengue mosquito, False myrrh.

Abstract

Tetradenia riparia (Hochst.) Codd (Lamiaceae) is a shrub, commonly known as ginger bush or false myrrh, and several studies have shown that T. riparia exhibits a variety of biological properties. This study aimed to determine the chemical composition of T. riparia essential oil and its fractions, investigate their anticholinesterase activity, and assess their larvicidal activity against the cattle tick Rhipicephalus microplus and the mosquito Aedes aegypti. Eleven essential oil fractions were obtained by fractionation and analyzed by gas chromatography/mass spectrometry. Larvicidal activity against R. microplus and third-instar A. aegypti was assessed using a larval packet test and a larval immersion test, respectively. Anticholinesterase activity was determined by a bioautographic method. Forty-nine compounds were identified in the essential oil, of which the major classes were oxygenated sesquiterpenes (45.95%) and sesquiterpene hydrocarbons (35.20%) and the major components were isospathulenol (17.40%), β-caryophyllene (15.61%), 14-hydroxy-9-epi-caryophyllene (10.07%), 14-hydroxy-α-muurolene (8.32%), and 9β,13β-epoxy-7-abietene (5.53%). Bioassays showed that T. riparia essential oil (LC₅₀ = 1.56 µg/mL) and FR3 (LC₅₀ = 0.30 µg/mL) were the most active against R. microplus and A. aegypti larvae, respectively. The essential oil and FR1, FR2, and FR3 exhibited acetylcholinesterase inhibitory activity. These results indicate that T. riparia essential oil and its fractions hold promise in the development of novel, environmentally safe agents for the control of R. microplus and A. aegypti larvae.

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