Impact of reminder on medication adherence: a structural equation model, based on study in Sikkim, India

Authors

DOI:

https://doi.org/10.14393/BJ-v38n0a2022-59087

Keywords:

Belief, Medication Adherence, Perception, Physician Advice, Reminder, Side Effect.

Abstract

The problem of medication non-adherence has persisted over decades. The rate of adherence decreases with time and improvement in health condition. When patients cannot follow their prescribed medication regime, it leads to deterioration of their health condition and increases their financial costs. This research aims to find the effect of reminder on medication adherence behaviour of patients when “Acceptance of Side Effect”, “Quality of Life” and “Medication Beliefs” act as mediators. The sample size of the research was 505. Sampling units comprised patients suffering from different diseases in Central Referral Hospital, Sikkim, India. By developing a Structural Equation Model, the effect of reminder on the mediators and adherence was analysed. The results show a significant positive association between reminder and the three mediators. Reminder has a significant positive effect on adherence (β=0.637, e=0.055, p=0.001). The effect is higher in the presence of mediators (β=0.7, e=0.037, p=0.001).

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References

ABDULLAH, N.Z.L., HALIM, S.A. and HAMIDI, F.W. Patient’s Perception on the Features of Interest and Barriers of Smartphone Medication Adherence Applications. Pharmacy Research Reports. 2020, 3(2), 29-39.

ARDIANTI, S., AGUSHYBANA, F. and NUGRAGA, P. The Influence Of Reminder Sms Intervention In Improving Drug Compliance In The Review Of Glycated Hemoglobin Levels (Hba1c) And Morisky Medical Capabilityscale (MMAS)-8 Dm Type 2 Patients In Community Health Centers Of Semarang City. International Journal of Health, Education and Social (IJHES). 2020, 3(1), 1–12. https://doi.org/10.1234/ijhes.v3i1.68

CAI, Q., et al. Patients’ adherence-related beliefs about inhaled steroids: application of the Chinese version of the Beliefs about Medicines Questionnaire-specific in patients with asthma. Journal of Asthma. 2020, 57(3), 319–326. https://doi.org/10.1080/02770903.2019.1565824

PIERNAVIEJA, L.C., et al. 4CPS-114 Beliefs about medication and quality of life in multiple sclerosis patients treated with natalizumab. European Journal of Hospital Pharmacy. 2020, 27(Suppl 1), A100.3-A101. https://doi.org/10.1136/ejhpharm-2020-eahpconf.215

CHOUDHRY, N.K., et al. Effect Of Reminder Devices On Medication Adherence: The REMIND Randomized Clinical Trial. JAMA Internal Medicine. 2017, 177(5), 624–631. https://doi.org/10.1001/jamainternmed.2016.9627

CHRISTENSEN, A.J., et al. Patient and physician beliefs about control over health: Association of symmetrical beliefs with medication regimen adherence. Journal of General Internal Medicine. 2010, 25(5), 397–402. https://doi.org/10.1007/s11606-010-1249-5

DUNN, D.S. and ELLIOTT, T.R. The Place and Promise of Theory in Rehabilitation Psychology Research. Rehabilitation Psychology. 2008, 53(3), 254–267. https://doi.org/10.1037/a0012962

GÜNER, T.A. and COŞANSU, G. The Effect Of Diabetes Education And Short Message Service Reminders on Metabolic Control And Disease Management In Patients With Type 2 Diabetes Mellitus. Primary Care Diabetes. 2020, 14(5), 482–487. https://doi.org/10.1016/j.pcd.2020.04.007

HABERER, J.E., et al. Effect of SMS Reminders on Prep Adherence in Young Kenyan Women (MPYA Study): A Randomised Controlled Trial. The Lancet HIV. 2021, 8(3), e130–e137. https://doi.org/10.1016/S2352-3018(20)30307-6

HALL, N.J., RUBIN, G.P., HUNGIN, A.P.S. and DOUGALL, A. Medication beliefs among patients with inflammatory bowel disease who report low quality of life: A qualitative study. BMC Gastroenterology, 2007, 7(1), 1–8. https://doi.org/10.1186/1471-230X-7-20

JIMENEZ, K., et al. Evaluating the Validity and Reliability of the Beliefs About Medicines Questionnaire in Low-Income, Spanish-Speaking Patients With Diabetes in the United States. Diabetes Educator. 2017, 43(1), 114–124. https://doi.org/10.1177/0145721716675740

KOOY, M.J., et al. Effects Of A Telephone Counselling Intervention By Pharmacist (Telcip) On Medication Adherence, Patient Beliefs And Satisfaction With Information For Patients Starting Treatment: Study Protocol For A Cluster Randomized Controlled Trial. BMC Health Services Research. 2014, 14(1), 219. https://doi.org/10.1186/1472-6963-14-219

LACHS, M.S. and HAN, S.D. Age-associated financial vulnerability: An emerging public health issue. Annals of Internal Medicine, 2015, 163(11), 877-878. https://doi.org/10.7326/M15-0882

LIN, S., MA, Y. and ZOU, H. A Brief Metric Framework For Patient Adherence To Doctor’s Advice Based On Behavioral Economics. Patient Preference and Adherence. 2020, 14, 371–381. https://doi.org/10.2147/PPA.S227829

LIU, X. and VARSHNEY, U. Mobile Health: A Carrot and Stick Intervention To Improve Medication Adherence. Decision Support Systems. 2020, 128, 113165. https://doi.org/10.1016/j.dss.2019.113165

MAGADZA, C., RADLOFF, S.E. and SRINIVAS, S.C. The effect of an educational intervention on patients’ knowledge about hypertension, beliefs about medicines, and adherence. Research in Social and Administrative Pharmacy. 2009, 5(4), 363–375. https://doi.org/10.1016/j.sapharm.2009.01.004

MOLS, F., et al. Are Illness Perceptions, Beliefs About Medicines And Type D Personality Associated With Medication Adherence Among Thyroid Cancer Survivors? A Study From The Population-Based PROFILES Registry. Psychology and Health. 2020, 35(2), 128–143. https://doi.org/10.1080/08870446.2019.1619730

NADERI, S.H., BESTWICK, J.P. and WALD, D.S. Adherence To Drugs That Prevent Cardiovascular Disease: Meta-Analysis On 376,162 Patients. American Journal of Medicine. 2012, 125(9), 882-887.e1. https://doi.org/10.1016/j.amjmed.2011.12.013

NEWMAN-CASEY, P.A., et al. The Impact of the Support, Educate, Empower Personalized Glaucoma Coaching Pilot Study on Glaucoma Medication Adherence. Ophthalmology. Glaucoma. 2020, 3(4), 228–237. https://doi.org/10.1016/j.ogla.2020.04.013

PARK, L.G., HOWIE-ESQUIVEL, J. and DRACUP, K. A Quantitative Systematic Review Of The Efficacy Of Mobile Phone Interventions To Improve Medication Adherence. Journal of Advanced Nursing. 2014, 70(9), 1932–1953. https://doi.org/10.1111/jan.12400

PENG, Y., et al. Effectiveness of Mobile Applications on Medication Adherence in Adults with Chronic Diseases: A Systematic Review and Meta-Analysis. Journal of Managed Care and Specialty Pharmacy. 2020, 26(4), 550–561. https://doi.org/10.18553/jmcp.2020.26.4.550

QIAO, X., et al. The association between frailty and medication adherence among community-dwelling older adults with chronic diseases: Medication beliefs acting as mediators. Patient Education and Counseling. 2020, 103(12), 2548-2554. https://doi.org/10.1016/j.pec.2020.05.013

RAHIMI, A., ZAKRI, H. and KHALIL, A. Development of Automatic Reminder System for Geriatric Medicine Intake. In Malaysian Journal of Science Health and Technology. 2021, 7(1), 8-14. https://doi.org/10.33102/MJOSHT.V7I1.152

RANJBARAN, S., et al. Determinants Of Medication Adherence Among Iranian Patients With Type 2 Diabetes: An Application Of Health Action Process Approach. Heliyon. 2020, 6(7), e04442. https://doi.org/10.1016/j.heliyon.2020.e04442

RODRIGUES, R., et al. The Phone Reminder Is Important, But Will Others Get To Know About My Illness? Patient Perceptions Of An Mhealth Antiretroviral Treatment Support Intervention In The HIVIND Trial In South India. BMJ Open. 2015, 5(11), e007574. https://doi.org/10.1136/bmjopen-2015-007574

SALAMA, H.M. and SAUDI, R.A. Effect Of Patients Beliefs About Medications On Adherence To Drugs In Diabetic Patients Attending Family Medicine Outpatient Clinic In Ismailia, Egypt. Journal of Diabetes and Metabolic Disorders. 2020, 19, 1–8. https://doi.org/10.1007/s40200-020-00587-0

SANTO, K., et al. Medication Reminder Apps To Improve Medication Adherence In Coronary Heart Disease (Medapp-CHD) Study: A Randomised Controlled Trial Protocol. BMJ Open. 2017, 7(10), e017540. https://doi.org/10.1136/bmjopen-2017-017540

SVARSTAD, B.L., CHEWNING, B.A., SLEATH, B.L. and CLAESSON, C. The Brief Medication Questionnaire: A Tool For Screening Patient Adherence And Barriers To Adherence. Patient Education and Counseling. 1999, 37(2), 113–124. https://doi.org/10.1016/S0738-3991(98)00107-4

TAN, J.W., KHOO, T.B., BURHARUDIN, N.F. and SHAH, N.M. Medication Self-Management Among Parents Of Children With Epilepsy At A Tertiary Care Center In Malaysia. Epilepsy and Behavior. 2020, 111, 107317. https://doi.org/10.1016/j.yebeh.2020.107317

THOMSEN, T., et al. A. Sustained Long‐Term Efficacy of Motivational Counseling and Text Message Reminders on Daily Sitting Time in Patients With Rheumatoid Arthritis: Long‐Term Follow‐up of a Randomized, Parallel‐Group Trial. Arthritis Care and Research. 2020, 72(11), 1560–1570. https://doi.org/10.1002/acr.24060

THOMSON, P., et al. Longitudinal Study Of The Relationship Between Patients’ Medication Adherence And Quality Of Life Outcomes And Illness Perceptions And Beliefs About Cardiac Rehabilitation. BMC Cardiovascular Disorders. 2020, 20(1), 71. https://doi.org/10.1186/s12872-020-01378-4

VON BLANCKENBURG, P., et al. Optimizing Expectations To Prevent Side Effects And Enhance Quality Of Life In Breast Cancer Patients Undergoing Endocrine Therapy: Study Protocol Of A Randomized Controlled Trial. BMC Cancer. 2013, 13(1), 1–10. https://doi.org/10.1186/1471-2407-13-426

WARD, J., et al. Shared Decision Making In Chronic Medication Use: Scenarios Depicting Exemplary Care. Research in Social and Administrative Pharmacy. 2020, 16 (1), 108–110. https://doi.org/10.1016/j.sapharm.2019.04.047

WILLIAMS, C.P. Importance Of Quality‐Of‐Life Priorities And Preferences Surrounding Treatment Decision Making In Patients With Cancer And Oncology Clinicians. Cancer. 2020, 126(15), 3534–3541. https://doi.org/10.1002/cncr.32961

ZELIKOVSKY, N. and NELSON, E. Illness Perceptions And Beliefs About Medication: Impact On Health‐Related Quality Of Life In Adolescent Kidney Transplant Recipients. Pediatric Transplantation. 2021, 25(3), e13988. https://doi.org/10.1111/petr.13988

ZHANG, X.P., et al. Factors Influencing Health Behaviour, Blood Pressure Control, And Disability In Hypertensive Ischaemic Stroke Patients After A Comprehensive Reminder Intervention. Journal of Advanced Nursing. 2020, 76(6), 1384–1393. https://doi.org/10.1111/jan.14340

ZOMAHOUN, H.T.V., et al. Effectiveness Of Motivational Interviewing Interventions On Medication Adherence In Adults With Chronic Diseases: A Systematic Review And Meta-Analysis. International Journal of Epidemiology. 2017, 46(2), 589–602. https://doi.org/10.1093/ije/dyw273

ZHANG, H., WU, J. and GUO, X. Effects of Antimicrobial and Antioxidant Activities Of Spice Extracts On Raw Chicken Meat Quality. Food Science and Human Wellness. 2016, 5(1), 39-48. https://doi.org/10.1016/j.fshw.2015.11.003

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Published

2022-02-16

How to Cite

SAHA, S.K. and JHA, A., 2022. Impact of reminder on medication adherence: a structural equation model, based on study in Sikkim, India. Bioscience Journal [online], vol. 38, pp. e38014. [Accessed20 May 2022]. DOI 10.14393/BJ-v38n0a2022-59087. Available from: https://seer.ufu.br/index.php/biosciencejournal/article/view/59087.

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Health Sciences