Synthesis, antimicrobial evaluation and in silico studies of the (E)-3-(aryl)-5-styryl-1,2,4-oxadiazoles

Authors

  • Josefa Aqueline da Cunha Lima Universidade Federal Rural de Pernambuco
  • Erick Caique Santos Costa Universidade Federal de Campina Grande https://orcid.org/0000-0003-4687-0725
  • Giselle Barbosa Bezerra Universidade Federal Rural de Pernambuco
  • Jadson de Farias Silva Universidade Federal Rural de Pernambuco
  • Rodrigo Ribeiro Alves Caiana Universidade Federal de Campina Grande https://orcid.org/0000-0002-7935-6143
  • Joao Rufino de Freitas Filho Universidade Federal Rural de Pernambuco
  • Juliano Carlo Rufino Freitas Universidade Federal de Campina Grande

DOI:

https://doi.org/10.14393/BJ-v38n0a2022-54382

Keywords:

Antimicrobial activity, In silico, Oxadiazole. Synthesis.

Abstract

In recent years, investigations in the field of oxadiazoles have been intensified due to their numerous therapeutic uses. Oxadiazoles are a class of compounds that exhibit several biological applications, citing antimicrobial, anti-inflammatory, anti-diabetic, anthelmintic, anti-tumor, among others. Encouraged by the biological potential of oxadiazoles, were carried out synthesis, antimicrobial evaluation and in silica studies of five (E)-3-(aryl)-5-styryl-1,2,4-oxadiazoles. In this way, (Z)-aryl-N'-hydroxybenzimidamides and ethyl (E)-cinnamate were synthesized, which were subjected to an O-acylamidoxime reaction after by dehydration using microwave irradiation to form the oxadiazole nucleus. The compounds were characterized by spectroscopic techniques, while in vitro antimicrobial activity was evaluated against S. aureus, E. faecalis, E. coli, P. aeruginosa, and against the fungus C. utilis using the microplate microdilution method. Thus, (Z)-aryl-N'-hydroxybenzimidamides, ethyl (E)-cinnamate, and (E)-3-(aryl)-5-styryl-1,2,4-oxadiazoles were synthesized with yields ranging from moderate to good. The (E)-3-(aryl)-5-styryl-1,2,4-oxadiazoles exhibited a reduced spectrum of action, which were active against the bacterium P. aeruginosa and for the fungus C. utilis.

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References

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Published

2022-02-16

How to Cite

LIMA, J.A. da C., COSTA, E.C.S., BEZERRA, G.B., SILVA, J. de F., ALVES CAIANA, R.R., DE FREITAS FILHO, J.R. and FREITAS, J.C.R., 2022. Synthesis, antimicrobial evaluation and in silico studies of the (E)-3-(aryl)-5-styryl-1,2,4-oxadiazoles. Bioscience Journal [online], vol. 38, pp. e38005. [Accessed10 August 2022]. DOI 10.14393/BJ-v38n0a2022-54382. Available from: https://seer.ufu.br/index.php/biosciencejournal/article/view/54382.

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Health Sciences