Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms
Keywords:Ginkgo, Excipients, Cell division, Cellular changes, Meristematic tissue
The toxic potential at the cellular level of industrialized Ginkgo biloba L. leaves was evaluated in meristematic cells of Allium cepa at concentrations of 0.1; 0.2 and 0.4 mg/ml. The industrialized products, from four pharmaceutical laboratories, were identified as A, B, C and D. Cell-level toxicity of dehydrated ginkgo leaf tea was also evaluated at concentrations of 0.15; 0.30 and 0.60 mg/ml. Dehydrated products were purchased from herbalists certified by ANVISA. The roots were exposed to teas and processed products for 24 and 48 hours. The results were submitted to the Chi-square test at 5%. However, industrialized ginkgo products at all concentrations caused antiproliferative effect. Also, the products purchased in pharmacies did not induce significant changes to root meristems. Therefore, industrialized ginkgo promoted cytotoxicity, however, they were not genotoxic to the bioassay used.
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Copyright (c) 2018 Clarice Moura Guedes, Fabelina Karollyne Silva dos Santos, Tamires Silva, Ana Paula Soares e Silva, Michele Vieira da Silva Lima, Valtânia Ana de Oliveira, Maria Eduarda Sousa Silva, Maria Carolina de Abreu, Ana Paula Paula Peron
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