Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms

Authors

  • Clarice Moura Guedes Universidade Federal do Piauí
  • Fabelina Karollyne Silva dos Santos Universidade Federal do Piauí
  • Tamires Silva Universidade Federal do Piauí
  • Ana Paula Soares e Silva Universidade Federal do Piauí
  • Michele Vieira da Silva Lima Universidade Federal do Piauí
  • Valtânia Ana de Oliveira Universidade Federal do Piauí
  • Maria Eduarda Sousa Silva Universidade Federal do Piauí
  • Maria Carolina de Abreu Universidade Federal do Piauí
  • Ana Paula Paula Peron Universidade Federal do Piauí

DOI:

https://doi.org/10.14393/BJ-v34n1a2018-39745

Keywords:

Ginkgo, Excipients, Cell division, Cellular changes, Meristematic tissue

Abstract

The toxic potential at the cellular level of industrialized Ginkgo biloba L. leaves was evaluated in meristematic cells of Allium cepa at concentrations of 0.1; 0.2 and 0.4 mg/ml. The industrialized products, from four pharmaceutical laboratories, were identified as A, B, C and D. Cell-level toxicity of dehydrated ginkgo leaf tea was also evaluated at concentrations of 0.15; 0.30 and 0.60 mg/ml. Dehydrated products were purchased from herbalists certified by ANVISA. The roots were exposed to teas and processed products for 24 and 48 hours. The results were submitted to the Chi-square test at 5%. However, industrialized ginkgo products at all concentrations caused antiproliferative effect. Also, the products purchased in pharmacies did not induce significant changes to root meristems. Therefore, industrialized ginkgo promoted cytotoxicity, however, they were not genotoxic to the bioassay used.

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Published

2018-08-08

How to Cite

GUEDES, C.M., SILVA DOS SANTOS, F.K., SILVA, T., E SILVA, A.P.S., LIMA, M.V. da S., OLIVEIRA, V.A. de, SILVA, M.E.S., ABREU, M.C. de and PERON, A.P.P., 2018. Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms . Bioscience Journal [online], vol. 34, no. 4, pp. 1017–1024. [Accessed29 November 2022]. DOI 10.14393/BJ-v34n1a2018-39745. Available from: https://seer.ufu.br/index.php/biosciencejournal/article/view/39745.

Issue

Section

Biological Sciences