Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich diet


  • Rafael Calais Gaspar Universidade Estadual de Campinas
  • Gabriel Keine Kuga Universidade Estadual Paulista Julio de Mesquita Filho, Post-graduate program in Movement Sciences
  • Vitor Rosetto Muñoz Universidade Estadual de Campinas
  • Andressa Coope Universidade Estadual de Campinas
  • Lucieli Teresa Cambri Universidade Federal do Mato Grosso
  • Ana Carolina Ghezzi Universidade Estadual de Campinas
  • Leandro Pereira de Moura Universidade Estadual de Campinas
  • José Alexandre Curiacos de Almeida Leme Universidade Estadual de Campinas
  • José Rodrigo Pauli Universidade Estadual de Campinas
  • José Diego Botezelli Universidade Estadual de Campinas



Physical Exercise, Overweight, Adiposity, Hepatic Steatosis


This study aims to examine the effects of physical training performed in early (preventive) or late (therapeutic) protocols on body weight gain, glucose tolerance, and triglycerides accumulation in rats fed on a fructose-rich diet. Wistar rats were allocated into two major groups according to the diet received: Control (C- standard diet) and Fructose (F- diet containing 60% fructose) fed during 120 days. Next, these two groups were distributed into six groups: C and F that were kept inactive; CTE (Control Trained Early) and FTE (Fructose Trained Early) that were submitted to Anaerobic Threshold (AnT) training from 28 to 120 days; CTL (Control Trained Late) and FTL (Fructose Trained Late) trained from 90 to 120 days. Physical Training was composed by swimming (5 days/week) at AnT determined by maximum lactate stead state (MLSS). The Oral Glucose Tolerance Test (oGTT) was performed 48h after the last in vivo analysis and did not showed differences between the groups. After, the animals were euthanized for heart, liver, and adipose tissue extraction. The early exercised animals had lower body weight compared to their sedentary littermates. Also, the fructose-rich diet increased liver lipids content in the sedentary animals and physical training successfully reduced this parameter in both major groups. These results suggests that physical training at the AnT performed in early or late protocols are effective to prevent and treat metabolic disorders related to fructose intake.


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How to Cite

GASPAR, R.C., KUGA, G.K., MUÑOZ, V.R., COOPE, A., CAMBRI, L.T., GHEZZI, A.C., DE MOURA, L.P., LEME, J.A.C. de A., PAULI, J.R. and BOTEZELLI, J.D., 2018. Physical training prevent and treat hepatic lipid accumulation induced by fructose-rich diet . Bioscience Journal [online], vol. 34, no. 4, pp. 1041–1050. [Accessed24 April 2024]. DOI 10.14393/BJ-v34n1a2018-39403. Available from:



Health Sciences