Assessment of hemodynamic parameters distribution in normal carotid artery by using computational fluid dynamics based on CE-MRA data

Authors

  • Xiao Li Shanghai Jiaotong University
  • Beibei Sun Shanghai Jiaotong University
  • Shiteng Suo Shanghai Jiaotong University
  • Xiaoqian Ge Shanghai Jiaotong University
  • Huilin Zhao Shanghai Jiaotong University
  • Yi Sun Shanghai Jiaotong University
  • Jianrong Xu Shanghai Jiaotong University
  • Bulang Gao Hebei Medical University
  • Xiaosheng Liu Shanghai Jiaotong University

DOI:

https://doi.org/10.14393/BJ-v34n2a2018-38002

Keywords:

Wall shear stress, Velocity, In-plane pressure difference, Computational fluid dynamics, Carotid atherosclerosis

Abstract

This study was to analyze the in vivo distribution of wall shear stress (WSS), velocity and in-plane pressure difference in normal carotid artery by using computational fluid dynamics (CFD) based on contrast-enhanced MRA (CE-MRA) data and to determine whether there were differences in these hemodynamic parameters between atherosclerosis-free and atherosclerosis-prone areas. CE-MRA was performed on 16 normal carotid arteries to obtain carotid three-dimensional surface data. CFD analysis was then performed to estimate those parameters in atherosclerosis-free (distal common carotid artery and distal internal carotid artery) and atherosclerosis-prone (carotid bifurcation) areas. One-way analysis of variance (ANOVA) was conducted to analyze differences among these three areas.

CFD analysis revealed that WSS and velocity were significantly lower in carotid bifurcation compared to distal common carotid artery (CCA) (P =0.011, P <0.001, respectively) and distal internal carotid artery (ICA) (P <0.001, P <0.001, respectively). While in-plane pressure difference was significantly higher in carotid bifurcation compared to distal CCA (P <0.001) and distal ICA (P =0.005). Hemodynamic environment in carotid bifurcation of normal carotid artery which assessed by using CFD analysis appeared to be with lower WSS and lower velocity, while with higher in-plane pressure difference. These characterizations might facilitate the initiation of atherosclerosis.

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Published

2018-03-27

How to Cite

LI, X., SUN, B., SUO, S., GE, X., ZHAO, H., SUN, Y., XU, J., GAO, B. and LIU, X., 2018. Assessment of hemodynamic parameters distribution in normal carotid artery by using computational fluid dynamics based on CE-MRA data . Bioscience Journal [online], vol. 34, no. 2, pp. 534–539. [Accessed2 December 2022]. DOI 10.14393/BJ-v34n2a2018-38002. Available from: https://seer.ufu.br/index.php/biosciencejournal/article/view/38002.

Issue

Section

Health Sciences