Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation

Authors

  • Wanessa da Silva Peres Bezerra Universidade Federal de Mato Grosso do Sul
  • Marcos Antonio Ferreira Júnior Universidade Federal de Mato Grosso do Sul http://orcid.org/0000-0002-9123-232X
  • Isabelle Campos de Azevedo Universidade Federal do Rio Grande do Norte http://orcid.org/0000-0001-5322-7987
  • Mayk Penze Cardoso Universidade Federal de Mato Grosso do Sul
  • Andreia Insabralde de Queiroz Cardoso Universidade Federal de Mato Grosso do Sul
  • Oleci Pereira Frota Universidade Federal de Mato Grosso do Sul
  • Maria Lúcia Ivo Universidade Federal de Mato Grosso do Sul
  • Vanessa Giavarotti Taboza Flores Universidade Federal de Mato Grosso do Sul
  • Elenilda de Andrade Pereira Gonçalves Universidade Católica Dom Bosco

DOI:

https://doi.org/10.14393/BJ-v35n5a2019-36227

Keywords:

Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation, Child, Adolescent, Epidemiology

Abstract

The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. To characterize the clinical and epidemiological profile of children and adolescents submitted to HSCT at a referral service in the state of Rio Grande do Norte. This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). The final sample consisted of 35 records patients aged between 2 and 18 years old who underwent HSCT from February 2008 to December 2015 and who presented the data necessary for the study. The records analyzed showed a little majority of male patients (51.42%) and 60.00% of these men were students and 71.42% lived in the state of the Rio Grande do Norte. According to the clinical characteristics, 34.3% of the patients had Acute Lymphoblastic Leukemia and 25.71% had Acute Myeloid Leukemia as the main diagnosis. Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. Septsis was the most frequent cause of death (60%). The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. These data are similar to studies conducted in North America, Europe and Asia.

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Author Biographies

Marcos Antonio Ferreira Júnior, Universidade Federal de Mato Grosso do Sul

Enfermeiro, Doutor em Saúde e Desenvolvimento, Professor dos Cursos de Graduação e Pós-Graduação em Enfermagem, Instituto Integrado de Saúde, Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brasil.

Isabelle Campos de Azevedo, Universidade Federal do Rio Grande do Norte

Enfermeira, Doutoranda em Enfermagem pelo Programa de Pós-graduação em Enfermagem e Professora Substituta do Curso de Graduação em Enfermagem da Universidade Federal do Rio Grande do Norte. Membro do grupo de pesquisa "Laboratório de Investigação do Cuidado, Segurança, Segurança, Tecnologias em Saúde e Enfermagem (LABTEC)", Natal, Rio Grande do Norte, Brasil.

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Published

2019-12-02

How to Cite

BEZERRA, W. da S.P., FERREIRA JÚNIOR, M.A., AZEVEDO, I.C. de, CARDOSO, M.P., CARDOSO, A.I. de Q., FROTA, O.P., IVO, M.L., FLORES, V.G.T. and GONÇALVES, E. de A.P., 2019. Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation. Bioscience Journal [online], vol. 35, no. 5, pp. 1622–1632. [Accessed9 December 2022]. DOI 10.14393/BJ-v35n5a2019-36227. Available from: https://seer.ufu.br/index.php/biosciencejournal/article/view/36227.

Issue

Section

Health Sciences