Selected ophthalmic and physiologic parameters in rabbits (Oryctolagus cuniculus) submitted to retrobulbar block with lidocaine, morphine or ketamine

Authors

  • Débora Passos Hinojosa Schaffer Universidade Federal da Bahia
  • Camila Pinho Balthazar da Silveira Universidade Estadual paulista "Júlio Mesquita Filho"
  • Newton Nunes Universidade Estadual paulista "Júlio Mesquita Filho"
  • José Luiz Laus Universidade Estadual paulista "Júlio Mesquita Filho"
  • Nayone Lima Lantyer Cordeiro de Araújo Universidade Federal da Bahia
  • Emanoel Ferreira Martins Filho Universidade Federal da Bahia
  • Arianne Pontes Oriá Universidade Federal da Bahia

DOI:

https://doi.org/10.14393/BJ-v33n5a2017-34909

Keywords:

dissociative anesthetics, eye, lagomorphs, local anesthesia, opioids

Abstract

The aim of the present study was to evaluate selected ophthalmic and physiologic parameters in rabbits submitted to retrobulbar blockade with lidocaine, morphine or ketamine. Eighteen adult rabbits, seven males and eleven females, New Zealand White breed, weighing 3.9 ± 0.7 kg were randomly assigned to perform the retrobulbar block according to the groups: LID (2% lidocaine without a vasoconstrictor - 7 mg kg-1); MOR (1% morphine - 1 mg kg-1) or KET (10% Ketamine - 5 mg kg-1). Ophthalmic and physiologic parameters were assessed, including lacrimal production using Schirmer tear test (STT), corneal touch threshold (CTT), pupillary diameter, intraocular pressure (IOP), pulse rate (PR), respiratory rate (RR), oxyhemoglobin saturation (SpO2), rectal temperature (RT) and systolic, mean and diastolic blood pressures (SAP, MAP and DAP) and were evaluated every 10 minutes for 70 minutes. All drugs used in the present study promoted central positioning of the eyeball for up to one minute later the retrobulbar administration in all cases. There was a significant increase of STT values in MOR and LID, when compared to baseline, while the CTT values had a significant decrease in all groups. KET kept the IOP values unaltered at the time points and there was a significant decrease of pupillary diameter in MOR. There was no significant change in PR, RR and SpO2; however, LID presented significantly lower values of SAP. MOR had increased values for RT when compared to the other two groups. The established parameters may help in ophthalmic procedures using retrobulbar nerve blocks.

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Author Biographies

Débora Passos Hinojosa Schaffer, Universidade Federal da Bahia

Departamento de Anatomia, Patologia e Clínicas Veterinárias

Camila Pinho Balthazar da Silveira, Universidade Estadual paulista "Júlio Mesquita Filho"

Departamento de Clínica e Cirurgia Veterinária

Newton Nunes, Universidade Estadual paulista "Júlio Mesquita Filho"

Departamento de Clínica e Cirurgia Veterinária

José Luiz Laus, Universidade Estadual paulista "Júlio Mesquita Filho"

Departamento de Clínica e Cirurgia Veterinária

Nayone Lima Lantyer Cordeiro de Araújo, Universidade Federal da Bahia

Departamento de Anatomia, Patologia e Clínicas Veterinárias

Arianne Pontes Oriá, Universidade Federal da Bahia

Departamento de Anatomia, Patologia e Clínicas Veterinárias

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Published

2017-09-21

How to Cite

SCHAFFER, D.P.H., DA SILVEIRA, C.P.B., NUNES, N., LAUS, J.L., DE ARAÚJO, N.L.L.C., MARTINS FILHO, E.F. and ORIÁ, A.P., 2017. Selected ophthalmic and physiologic parameters in rabbits (Oryctolagus cuniculus) submitted to retrobulbar block with lidocaine, morphine or ketamine . Bioscience Journal [online], vol. 33, no. 5, pp. 1257–1267. [Accessed7 December 2022]. DOI 10.14393/BJ-v33n5a2017-34909. Available from: https://seer.ufu.br/index.php/biosciencejournal/article/view/34909.

Issue

Section

Agricultural Sciences