Supplementation of S-allyl cysteine improves health span in Caenorhabditis elegans

Authors

  • Jun-Sung Kim Department of Medical Biotechnology, College of Medical Sciences, Soonchunhyang University, Asan, Chungnam, Republic of Korea
  • Sang-Kyu Park Department of Medical Biotechnology, College of Medical Sciences, Soonchunhyang University, Asan, Chungnam, Republic of Korea

DOI:

https://doi.org/10.14393/BJ-v33n2-32846

Keywords:

S-allyl cycteine, C. elegans, health span, motility, Aβ-toxicity

Abstract

Previous studies show that nutritional interventions with anti-oxidants have various health-promoting effects in several model organisms. Here, we examine the effects of S-allyl cysteine on resistance to environmental stressors and age-related physiological changes using C. elegans as a model system. S-allyl cysteine is a modified amino acid found in aged garlic extracts and known to have strong antioxidant activity. The survival of worms under oxidative-stress conditions significantly increased with supplementation of S-allyl cysteine. In addition, pre-treatment of S-allyl cysteine significantly increased resistance to both heat stress and ultraviolet irradiation. However, lifespan was not affected by S-allyl cysteine treatment. We also examined the effect of S-allyl cysteine on motility of C. elegans and found that S-allyl cysteine can retard the age-related decline of muscle tissue locomotive activity. S-allyl cysteine also significantly suppressed amyloid β-induced paralysis in Alzheimer's disease model animals. Taken together, our study indicates that dietary supplementation of S-allyl cysteine can improve health span and suggests that S-allyl cysteine can be used to develop novel health-promoting pharmaceuticals. 

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Author Biography

Sang-Kyu Park, Department of Medical Biotechnology, College of Medical Sciences, Soonchunhyang University, Asan, Chungnam, Republic of Korea

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Published

2017-03-30

How to Cite

KIM, J.-S. and PARK, S.-K., 2017. Supplementation of S-allyl cysteine improves health span in Caenorhabditis elegans . Bioscience Journal [online], vol. 33, no. 2. [Accessed8 December 2022]. DOI 10.14393/BJ-v33n2-32846. Available from: https://seer.ufu.br/index.php/biosciencejournal/article/view/32846.

Issue

Section

Biological Sciences