Markers of mitochondrial energy metabolism and their potential relationships with fatigue in human adults: a scoping review

Alan Vinicius Assunção-Luiz; Paulo Victor Borges; Bruna Tavares Bacalá; Jennifer Thalita Targino dos Santos; Letitia Graves; Leorey Saligan; Lucila Castanheira Nascimento; Milena Flória Santos

doi:10.14393/BJ-v38n0a2022-65195

Autores

Alan Vinicius Assunção-Luiz Universidade de São Paulo https://orcid.org/0000-0003-3644-3981
Paulo Victor Borges Universidade de São Paulo https://orcid.org/0000-0002-3037-8683
Bruna Tavares Bacalá Universidade de São Paulo https://orcid.org/0000-0002-7641-7465
Jennifer Thalita Targino dos Santos Universidade de São Paulo https://orcid.org/0000-0003-1733-5790
Letitia Graves National Institutes of Health https://orcid.org/0000-0002-6443-0566
Leorey Saligan National Institutes of Health https://orcid.org/0000-0001-9481-7836
Lucila Castanheira Nascimento Universidade de São Paulo https://orcid.org/0000-0002-7900-7111
Milena Flória Santos Universidade de São Paulo https://orcid.org/0000-0002-0656-1736

DOI:

https://doi.org/10.14393/BJ-v38n0a2022-65195

Palavras-chave:

Energy metabolism, Fatigue, Mitochondria, Oxidative phosphorylation, Review.

Resumo

This scoping review aimed to synthesize the best available evidence of the associations between molecular and genetic markers of mitochondrial metabolism and fatigue in human adults. The research question guiding this review was, “Are there potential relationships between mitochondrial metabolism markers and fatigue?” The literature search used three terms (mitochondria; fatigue; energy metabolism), which yielded 263 manuscripts and 22 theses/dissertations. The studies included in the review had to meet three criteria: (1) Include adult participants (≥18 years of age); (2) Show a relationship between mitochondrial energy metabolism and fatigue; (3) Be published in English, Spanish, or Portuguese. Of the 17 articles included for a full-text review, some had a cross-sectional design (6/17, 35%), and more than half (12/17, 70%) were published between 2015 and 2020. The predominant population studied were patients diagnosed with chronic fatigue syndrome (9/17, 53%). Most studies (15/17, 88%) assessed fatigue with validated instruments. Mitochondrial markers associated with fatigue are a) mitochondrial transport pathways and respiratory chain, b) mutations in mitochondrial DNA, and c) energy disorders in cells of the immune system, such as natural killer cells. Mitochondrial metabolic activities, such as the production and transport of ATP, are significant components that may help understand the etiology of fatigue. Future directions should include longitudinal study designs, characterization of fatigue phenotypes, and the identification of markers involved in production and transport pathways. The clinical relevance in this field can lead to interventions targeting mitochondrial markers to reduce or prevent fatigue.

Downloads

Não há dados estatísticos.

Referências

ALLARD, N.A.E., et al. Statins Affect Skeletal Muscle Performance: Evidence for Disturbances in Energy Metabolism. The Journal of Clinical Endocrinology & Metabolism. 2018, 103(1), 75–84. https://doi.org.10.1210/jc.2017-01561

AL MAQBALI, M., et al. Prevalence of Fatigue in Patients With Cancer: A Systematic Review and Meta-Analysis. Journal of pain and symptom management. 2021, 61(1), 167–189. https://doi.org/10.1016/j.jpainsymman.2020.07.037

ARKSEY, H. and O’MALLEY, L. Scoping studies: towards a methodological framework. International journal of social research methodology. 2005, 8(1), 19-32. https://doi.org.10.1080/1364557032000119616

BELL D.S. The Doctor’s Guide to Chronic Fatigue Syndrome. New York: Da Capo Press, 1994.

BOOTH, N. E., MYHILL, S. and MCLAREN-HOWARD, J. Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). International journal of clinical and experimental medicine. 2012, 5(3), 208.

CAMPANELLA, M., et al. IF1, the endogenous regulator of the F(1)F(o)-ATP synthase, defines mitochondrial volume fraction in HeLa cells by regulating autophagy. Biochim. Biophys. 2009, 1787(5), 393–401. https://doi.org.10.1016/j.bbabio.2009.02.023

DIAS, L.G., et al. Evaluation of anxiety, depression and stress symptoms in men with prostate cancer during the preoperative period. Bioscience Journal [online]. 2020, 36(5), 1760–1770. https://doi.org/10.14393/BJ-v36n5a2020-48103

DOERR, J.M., et al. Differential associations between fatigue and psychobiological stress measures in women with depression and women with somatic symptom disorder. Psychoneuroendocrinology. 2021, 132, 105343. https://doi.org/10.1016/j.psyneuen.2021.105343

FENG, L.R., et al. Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue. Journal of Visualized Experiments. 2018, 135, e57736. https://doi.org.10.3791/57736

FENG, L.R., et al. Cancer‑related fatigue during combined treatment of androgen deprivation therapy and radiotherapy is associated with mitochondrial dysfunction. International Journal of Molecular Medicine. 2020. 45(2), 485-496. https://doi.org.10.3892/ijmm.2019.4435

FERNANDEZ-GUERRA, P., et al. Bioenergetic and Proteomic Profiling of Immune Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients: An Exploratory Study. Biomolecules. 2021, 11, 961. https://doi.org/10.3390/biom11070961

GARCIA-BERMUDEZ, J. and CUEZVA, J.M. The ATPase Inhibitory Factor 1 (IF1): A master regulator of energy metabolism and of cell survival. Biochim. Biophys. 2016, 1857(8), 1167–1182. https://doi.org.10.1016/j.bbabio.2016.02.004

GHEITA, A.A., GHEITA, T.A. and KENAWY, S.A. The potential role of B5: A stitch in time and switch in cytokine. Phytotherapy research: PTR. 2020, 34(2), 306–314. https://doi.org/10.1002/ptr.6537

HAMILTON, D. and JENSEN, G.S. Nutraceutical support of mitochondrial function associated with reduction of long-term fatigue and inflammation. Alternative therapies in health and medicine. 2021, 27(3), 8–18.

HERPICH, C., et al. Age-related fatigue is associated with reduced mitochondrial function in peripheral blood mononuclear cells. Experimental gerontology. 2021, 144, 111177. https://doi.org/10.1016/j.exger.2020.111177

HSIAO, C.P., et al. Differential expression of genes related to mitochondrial biogenesis and bioenergetics in fatigued prostate cancer men receiving external beam radiation therapy. Journal of pain and symptom management. 2014, 48(6), 1080-1090. https://doi.org.10.1016/j.jpainsymman.2014.03.010

HSIAO, C.P., et al. Relationships between expression of BCS1L, mitochondrial bioenergetics, and fatigue among patients with prostate cancer. Cancer Management and Research. 2019, 11, 6703-6717. https://doi.org.10.2147/CMAR.S203317

HSIAO, C.P., et al. Possible bioenergetic biomarker for chronic Cancer-Related Fatigue. Nursing research. 2021, 70(6), 475–480. https://doi.org/10.1097/NNR.0000000000000547

JOSEPH, P., et al. Insights from invasive cardiopulmonary exercise testing of patients with myalgic encephalomyelitis/chronic fatigue syndrome. Chest. 2021, 160(2), 642–651. https://doi.org/10.1016/j.chest.2021.01.082

KORZENIEWSKI, B. Effect of training on skeletal muscle bioenergetic system in patients with mitochondrial myopathies: A computational study. Respiratory physiology & neurobiology. 2022, 296, 103799. https://doi.org/10.1016/j.resp.2021.103799

KRUPP, L.B., et al. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neuro. 1989, 46(10), 1121–1123. https://doi.org.10.1001/archneur.1989.00520460115022

LAU, C.I., et al. Increased risk of chronic fatigue syndrome in patients with migraine: A retrospective cohort study. Journal of Psychosomatic Research. 2015, 79, 514-518. https://doi.org/10.1016/j.jpsychores.2015.10.005

LEE, K., GAN, W.S. and CHRISTOPOULOS, G. Biomarker-Informed Machine Learning Model of Cognitive Fatigue from a Heart Rate Response Perspective. Sensors (Basel, Switzerland). 2021, 21(11), 3843. https://doi.org/10.3390/s21113843

LUTGENDORF, S.K. and SOOD, A.K. Biobehavioral factors and cancer progression: physiological pathways and mechanisms. Psychosomatic medicine, 2011, 73(9), 724. https://doi.org.10.1097/PSY.0b013e318235be76

MYHILL, S., BOOTH, N.E. and MCLAREN-HOWARD, J. Chronic fatigue syndrome and mitochondrial dysfunction. Int J Clin Exp Med. 2009, 2(1), 1-16.

MISSAILIDIS, D., et al. An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients. International Journal of Molecular Science. 2020, 21(3), 1074.

NGUYEN, T., et al. Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/chronic fatigue syndrome patients: A preliminary investigation. Asian Pacific Journal of Allergy and Immunology. 2018, 37(2), 102-108. https://doi.org/10.12932/AP-011117-0188

NORBURY, R., et al. The effect of elevated muscle pain on neuromuscular fatigue during exercise. European journal of applied physiology. 2022, 122(1), 113–126. https://doi.org/10.1007/s00421-021-04814-1

OUZZANI, M., et al. Rayyan — a web and mobile app for systematic reviews. Systematic Reviews. 2016, 5(1), 210. https://doi.org/10.1186/s13643-016-0384-4

PEOPLES, A.R., et al. Effect of exercise on muscle immune response and mitochondrial damage and their relationship with cancer-related fatigue: A URCC NCORP study. Patient and survivor care. 2017, 35(15), 10119-10119. https://doi.org/10.1200/JCO.2017.35.15_suppl.10119

PIERCE, J.D., et al. Study Protocol, randomized controlled trial: reducing symptom burden in patients with heart failure with preserved ejection fraction using ubiquinol and/or D-ribose. BMC Cardiovascular Disorders. 2018, 18(1), 57. https://doi.org/10.1186/s12872-018-0796-2

PAGE M.J., et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372(71). https://doi.org/10.1136/bmj.n71

PIPER, B.F. and CELLA, D. Cancer-related fatigue: definitions and clinical subtypes. J Natl Compr Canc Netw. 2010, 8(8), 958–966. https://doi.org/10.6004/jnccn.2010.0070

REUTER, S.E. and EVANS, A.M. Long‐chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase‐I activity. Journal of internal medicine. 2011, 270(1), 76-84. https://doi.org/10.1111/j.1365-2796.2010.02341.x

RUSIN, A., et al. Radiation exposure and mitochondrial insufficiency in chronic fatigue and immune dysfunction syndrome. Medical hypotheses. 2021, 154, 110647. https://doi.org/10.1016/j.mehy.2021.110647

SALIGAN, L.N., et al. A Development of a clinician-administered National Institutes of Health-Brief Fatigue Inventory: a measure of fatigue in the context of depressive disorders. Journal of psychiatric research. 2015, 68, 99-105. https://doi.org/10.1016/j.jpsychires.2015.06.012

SALIGAN, L.N., et al. An assessment of the anti-fatigue effects of ketamine from a double-blind, placebo-controlled, crossover study in bipolar disorder. Journal of affective disorders. 2016, 194, 115-119. https://doi.org/10.1016/j.jad.2016.01.009

SCHAEFER, A.M., et al. Endocrine disorders in mitochondrial disease. Molecular and Cellular Endocrinology. 2013, 379(1-2), 2–11. https://doi.org/10.1016/j.mce.2013.06.004

SURAPANENI, R., et al. Stage I lung cancer survivorship: risk of second malignancies and need for individualized care plan. Journal of Thoracic Oncology. 2012, 7(8), 1252-1256. https://doi.org/10.1097/JTO.0b013e3182582a79

TOMAS, C., et al. Cellular bioenergetics is impaired in patients with chronic fatigue syndrome. PLoS ONE. 2017, 12(10), e0186802. https://doi.org/10.1371/journal.pone.0186802

VERMEULEN, R.C.W., et al. Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity. Journal of Translational Medicine. 2010, 8(93), 1-7. https://doi.org/10.1186/1479-5876-8-93

WANG, J., CAMPBELL, I.L. and ZHANG, H. Systemic interferon-α regulates interferon-stimulated genes in the central nervous system. Molecular psychiatry. 2008, 13(3), 293. https://doi.org/10.1038/sj.mp.4002013

WAWRZYNIAK, N.R., et al. Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle. Oncotarget. 2016, 7(33), 52695. https://doi.org/10.18632/oncotarget.10685

WU, I., et al. Characteristics of Cancer-Related Fatigue and Concomitant Sleep Disturbance in Cancer Patients. Journal of pain and symptom management. 2022, 63(1), e1–e8. https://doi.org/10.1016/j.jpainsymman.2021.07.025

YELLEN S.B., et al. Measuring fatigue and other anemia-related symptoms with the functional assessment of cancer therapy (FACT) measurement system. J Pain Symptom Manage. 1997. 13, 63-74.