Prevalência de alterações orais e salivares em pacientes com falha renal crônica em hemodiálise: Revisão sistemática e metanálise
DOI:
https://doi.org/10.14393/BJ-v39n0a2023-63061Palavras-chave:
Chronic Renal Failure, Salivary pH, Hyposalivation, Salivary Changes, Xerostomia.Resumo
O objetivo deste trabalho foi avaliar, por meio de revisão sistemática seguida de metanálise, se indivíduos com insuficiência renal crônica (IRC) associada a hemodiálise apresentam alterações salivares e da mucosa oral quando comparados a indivíduos saudáveis. Foi realizada uma revisão sistemática da literatura, avaliando ensaios clínicos randomizados encontrados nas bases de dados Proquest, Embase, Scopus, Cochrane Library, Web of Science, Lilacs e Pubmed, utilizando termos MeSH e outras palavras-chave. Inicialmente, 40 artigos foram incluídos no estudo e, após a leitura dos artigos completos, foram elegíveis 15 ensaios clínicos que analisaram lesões orais e alterações salivares em pacientes com IRC incluindo tratamento hemodialítico. A maioria dos estudos clínicos incluídos foi transversal e composta por um grupo de estudo e um grupo controle. A média de idade dos participantes do grupo de estudo foi de 50,19 anos e do grupo controle de 48,95 anos. As alterações orais mais comuns encontradas no grupo IRC em relação ao grupo controle foram: xerostomia, hálito urêmico, disgeusia, língua saburrosa, sangramento gengival e mucosa pálida. O fluxo salivar dos pacientes com IRC foi 46,6% menor que o do grupo controle. O pH salivar do grupo de estudo também foi mais alcalino quando comparado ao grupo controle. Maiores quantidades de ureia, fosfato, proteína C reativa e proteínas totais foram encontradas na saliva de indivíduos com IRC. Indivíduos com IRC em hemodiálise estão mais sujeitos a alterações tanto na quantidade quanto na qualidade da saliva, além de apresentarem maior quantidade de alterações orais.
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Copyright (c) 2023 Vanessa Cardoso dos Santos, Diego José Gambin, Keli Adriana Silvestre Casanova, Filipe Colombo Vitali, Letícia Copatti Dogenski, Thais Mageste Duque, Micheline Sandini Trentin, João Paulo De Carli
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