COVID LONGA E FATORES ASSOCIADOS EM INDIVÍDUOS DO SUL DO BRASIL: UM ESTUDO DE BASE POPULACIONAL SULCOVID-19

Autores

DOI:

https://doi.org/10.14393/Hygeia2070242

Palavras-chave:

COVID longa, Estudo Transversal, Infecção por Coronavírus, Adultos, Epidemiologia

Resumo

O objetivo do presente estudo foi verificar a prevalência e os fatores associados à COVID-19 e descrever os principais sintomas residuais em indivíduos do extremo sul do Brasil. Trata-se de um estudo transversal com 2.919 indivíduos maiores de 18 anos diagnosticados com COVID-19 no período de dezembro de 2020 a março de 2021 e que continuaram com sintomas após 6-9 meses de infecção. A prevalência de COVID longa foi de 48,3% (IC 95% 46,5; 50,1). Os sintomas residuais mais prevalentes foram fadiga, perda de memória, perda de atenção, dor de cabeça, perda do olfato, dor muscular e perda do paladar. Os grupos mais propensos a desenvolver COVID longa eram do sexo feminino, apresentavam ansiedade, hipertensão arterial, problemas cardíacos, diabetes mellitus, problemas musculoesqueléticos, problemas respiratórios, morbidades prévias e internação hospitalar. Atividade física e autopercepção de saúde boa e muito boa foram fatores de proteção para o desfecho. Quando ajustados, sexo feminino, ansiedade, morbidades e internação hospitalar permaneceram associados ao desfecho. Este estudo mostrou que metade dos indivíduos desenvolveu COVID longa após 6-9 meses de infeção, destacam-se os indivíduos do sexo feminino e os portadores de condições crônicas, demandando a criação de políticas públicas que promovam a assistência integral e continuada a eles.

Downloads

Não há dados estatísticos.

Referências

ANONYMOUS. Meeting the challenge of long COVID. Nat Med, v. 26, n. 12, p. 1803, 2020. DOI: https://doi.org/10.1038/s41591-020-01177-6

ASSOCIAÇÃO BRASILEIRA DE EMPRESAS DE PESQUISAS (ABEP). Critério de classificação econômica Brasil 2021. 2021;1–7. Disponível em: https://www.abep.org/criterio-brasil.

AUGUSTIN, M. et al. Post-COVID syndrome in non-hospitalized patients with COVID-19: a longitudinal prospective cohort study. Lancet Reg Heal Eur, v. 6:100122, jul. 2021. DOI: https://doi.org/10.1016/j.lanepe.2021.100122

BADENOCH, J. B. et al. Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis. Brain communications, v. 4, n. 1, p. fcab297, 2022. DOI: https://doi.org/10.1093/braincomms/fcab297

BALDIN, T. et al. Cerebral venous thrombosis and severe acute respiratory syndrome coronavirus‐2 infection: a systematic review and meta‐analysis. European Journal of Neurology, v. 28, n. 10, p. 3478-3490, 2021. https://doi.org/10.1111/ene.14727

BARSKY, A. J.; PEEKNA, H. M.; BORUS, J. F. Somatic symptom reporting in women and men. Journal of General Internal Medicine, v. 16, n. 4, p. 266-275, 2001. https://doi.org/10.1046/j.1525-1497.2001.016004266.x.

BECKER, C. et al. Long COVID 1 year after hospitalization for COVID-19: a prospective bicentric cohort study. Swiss Medical Weekly, v. 151, n. 4142, p. w30091-w30091, 2021. https://doi.org/10.4414/SMW.2021.w30091

BILLI, A. et al. Sex bias in autoimmunity. Current opinion in rheumatology, v. 31, n. 1, p. 53, 2019. https://doi.org/10.1097/BOR.0000000000000564

BLIDDAL, S. et al. Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients. Scientific Reports, v. 23, n. 1, p. 131-153, 2021. https://doi.org/10.1038/s41598-021-92045-x

BLOMBERG, B. et al. Long COVID in a prospective cohort of home-isolated patients. Nature Medicine, v. 27, n. 9, p. 1607–1613, jun. 2021. https://doi.org/10.1038/s41591-021-01433-3

BWIRE, G. M. Coronavirus: why men are more vulnerable to Covid-19 than women?. SN Comprehensive Clinical Medicine, v. 2, n. 7, p. 874-876, 2020. https://doi.org/10.1007/s42399-020-00341-w

CHEN CHEN, S. R. H. et al. Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review. The Journal of Infectious Diseases, v. 226, n. 9, p. 1593–1607, 2022. https://doi.org/10.1093/infdis/jiac136

COVITEL. Observatório da APS - Umane. 2022;1–2. Disponível em: http://observatoriodaaps.com.br/covitel/.

DAVIS, H. E. et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine, v. 38, 2021. https://doi.org/10.1016/j.eclinm.2021.101019

FERNÁNDEZ-DE-LAS-PEÑAS, C. et al. Symptoms Experienced at the Acute Phase of SARS-CoV-2 Infection as Risk Factor of Long-term Post-COVID Symptoms: The LONG-COVID-EXP-CM Multicenter Study. Int J Infect Dis, v. 116, p. 241–244, mar. 2022. https://doi.org/10.1016/j.ijid.2022.01.007

FERNÁNDEZ-DE-LAS-PEÑAS, C. et al. Female sex is a risk factor associated with long-term post-COVID related-symptoms but not with COVID-19 symptoms: the LONG-COVID-EXP-CM multicenter study. Journal of Clinical Medicine, v. 11, n. 2, p. 413, 2022. https://doi.org/10.3390/jcm11020413

GAMA, B. D. S.; CAVALCANTE, K. N. Pandemia do covid-19: acometimento neurológico e os impactos cerebrais / Covid-19 pandemic: neurological environment and brain impacts. Brazilian J Heal Ver, v. 3, n. 6, 2020. https://doi.org/10.34119/bjhrv3n6-285

GAROUT, M. A. et al. Post-COVID-19 syndrome: assessment of short- and long-term post-recovery symptoms in recovered cases in Saudi Arabia. Infection, v. 50, n. 6, p. 1431-1439, mar. 2022. https://doi.org/10.1007/s15010-022-01788-w

GONZÁLEZ, A. et al. Long COVID in hospitalized and non-hospitalized patients in a large cohort in Northwest Spain, a prospective cohort study. Sci Rep, n.12, n. 1, Mar. 2022. DOI:

https://doi.org/10.1038/s41598-022-07414-x

GREENHALGH, T. et al. Management of post-acute covid-19 in primary care. BMJ., v. 1, n. 370:m3026, ago. 2020. https://doi.org/10.1136/bmj.m3026

HUANG, C. et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. The Lancet, v. 397, n. 10270, p. 220-232, 2021. https://doi.org/10.1016/S0140-6736(20)32656-8

INSTITUTO BRASILEIRO DE GEOGRAFIA E ESTATÍSTICA (IBGE). Informações por cidade e estado. 2023; Disponível em: https://cidades.ibge.gov.br/brasil/rs/rio-grande/panorama.

JUNIOR, S. S. D. et al. Recuperação de déficit de memória pós COVID-19: uma revisão. Rev Ciências Biológicas e da Saúde, 1-10, set-dez. 2021.

KARAARSLAN F, DEMIRCIOĞLU GÜNERI F, KARDEŞ S. Postdischarge rheumatic and musculoskeletal symptoms following hospitalization for COVID-19: prospective follow-up by phone interviews. Rheumatol Int, v. 41, n. 7, p. 1263-71, 2021. DOI:

https://doi.org/10.1007/s00296-021-04882-8

KASHIF, A. et al. Follow-up of COVID-19 recovered patients with mild disease. Scientific Reports, v. 11, n. 1, p. 13414, 2021. https://doi.org/10.1038/s41598-021-92717-8

KENNY, G. et al. Identification of distinct long COVID clinical phenotypes through cluster analysis of self-reported symptoms. In: Open forum infectious diseases. US: Oxford University Press, 2022. p. ofac060. https://doi.org/10.1093/ofid/ofac060

LOPEZ-LEON, S. et al., More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. Sci Rep., v. 11, n. 1:1-22, ago. 2021. https://doi.org/10.1038/s41598-021-95565-8

LORENT, N. et al. Prospective longitudinal evaluation of hospitalized COVID-19 survivors 3 and 12 months after discharge. ERJ Open Res, v. 8, n. 2, abr. 2022. https://doi.org/10.1183/23120541.00004-2022

LUCCHETTA, R. et al. Possíveis desfechos de longo prazo da COVID-19: uma revisão sistemática de escopos. J Heal Biol Sci., v. 9, n. 1:1, p. 1-8. 2021. https://doi.org/10.12662/2317-3076jhbs.v9i1.3977.p1-8.2021

MAHASE, E. Covid-19: What do we know about "long covid"? BMJ, v. 370, jul. 2020. DOI:

https://doi.org/10.1136/bmj.m2815

MAHMOUD, M. H. et al. Study of post-COVID-19 syndrome in Saudi Arabia. Cureus, v. 13, n. 9, 2021. https://doi.org/10.7759/cureus.17787

MAO, L. et al. Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study. MedRxiv, p. 2020.02. 22.20026500, 2020. DOI:

https://doi.org/10.1101/2020.02.22.20026500

MARTIMBIANCO, A. L. C. et al. Frequency, signs and symptoms, and criteria adopted for long COVID: A systematic review. Int J Clin Pract, v. 75, n. 10:e14357, out. 2021. DOI:

https://doi.org/10.1111/ijcp.14357

MOHAMED-HUSSEIN, A. A. R. et al. Non-hospitalized COVID-19 patients have more frequent long COVID symptoms. The International Journal of Tuberculosis and Lung Disease, v. 25, n. 9, p. 732-737, 2021. https://doi.org/10.5588/ijtld.21.0135

NGUYEN, H. C. et al. People with suspected COVID-19 symptoms were more likely depressed and had lower health-related quality of life: The potential benefit of health literacy. J Clin Med. v. 9, n. 4, mar. 2020. https://doi.org/10.3390/jcm9040965

OLIVEIRA, R. de C. S. de et al. Síndrome pós-Covid-19: breve revisão. Brazilian J Heal Ver, v. 5, n. 2, 2022.https://doi.org/10.34119/bjhrv5n2-150

ORGANIZAÇÃO MUNDIAL DA SAÚDE (OMS). Pandemia da doença de coronavírus (COVID-19).2021. Disponível em: https://www.paho.org/pt/covid19#:~:text=A%20COVID%2D19%20%C3%A9%20a,na%20Rep%C3%BAblica%20Popular%20da%20China. Acesso em: 02/09/2021.

ORTONA, E. et al. Long COVID: an estrogen-associated autoimmune disease? Cell Death Discovery, v. 7, n. 1, p. 77, 2021. https://doi.org/10.1038/s41420-021-00464-6

PALMER, S. J. Long COVID and mental health. British Journal of Community Nursing, v. 26, n. 8, p. 406-409, 2021. https://doi.org/10.12968/bjcn.2021.26.8.406

PETERSEN, M. S. et al. Long COVID in the Faroe Islands: A Longitudinal Study among Non-hospitalized Patients. Clin Infect Dis., v. 73, n. 11, p. e4058-e4063, dez. 2021. https://doi.org/10.1093/cid/ciaa1792

PRIETO, M. A.; PRIETO, O.; CASTRO, H. M. [Long covid: cross-sectional study]. Rev Fac Cien Med Univ Nac Cordoba, v. 78, n. 1, p. 33-36, mar. 2021https://doi.org/10.31053/1853.0605.v78.n1.32048

RIGONI, M. et al. "Long COVID" results after hospitalization for SARS-CoV-2 infection. Scientific Reports, v. 12, n. 1, p. 9581, 2022. https://doi.org/10.1038/s41598-022-13077-5

ROGERS, J. P. et al. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. The Lancet Psychiatry, v. 7, n. 7, p. 611-627, 2020. https://doi.org/10.1016/S2215-0366(20)30203-0

SALARI, N. et al. Prevalence of stress, anxiety, depression among the general population during the COVID-19 pandemic: a systematic review and meta-analysis. Globalization and health, v. 16, n. 1, p. 1-11, 2020. https://doi.org/10.1186/s12992-020-00589-w

SECRETARIA DE SAÚDE. Painel Coronavírus RS. Disponível em: https://ti.saude.rs.gov.br/covid19/. Acesso em: 02/05/2021.

SCHERLINGER, M. et al. Refining "Long-COVID" by a Prospective Multimodal Evaluation of Patients with Long-Term Symptoms Attributed to SARS-CoV-2 Infection. Infect Dis Ther , v. 10, n. 3, p. 1747-1763, set. 2021. https://doi.org/10.1007/s40121-021-00484-w

SEANG, S. et al. Long COVID symptoms: Clinical characteristics and recovery rate among non-severe outpatients over a six-month follow-up. Infect Dis now, v. 52, n. 3, p. 165-169, mai. 2022. https://doi.org/10.1016/j.idnow.2022.02.005

SCHOU, T. M. et al. Psychiatric and neuropsychiatric sequelae of COVID-19-A systematic review. Brain, behavior, and immunity, v. 97, p. 328-348, 2021. https://doi.org/10.1016/j.bbi.2021.07.018

SUDRE, C. H. et al. Attributes and predictors of long COVID. Nature Medicine, v. 27, n. 4, p. 626-631, 2021. https://doi.org/10.1038/s41591-021-01292-y

SZWARCWALD, C. L. et al. Factors affecting Brazilians' self-rated health during the COVID-19 pandemic. Cadernos de Saúde Pública, v. 37, 2021. https://doi.org/10.1590/0102-311x00182720

TAQUET, M. et al. Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19. PLoS medicine, v. 18, n. 9, p. e1003773, 2021. https://doi.org/10.1371/journal.pmed.1003773

TAVARES, C. A. M. et al. ACE2 expression and risk factors for COVID-19 severity in patients with advanced age. Arquivos Brasileiros de Cardiologia, v. 115, p. 701-707, 2020. https://doi.org/10.36660/abc.20200487

TENFORDE, M. W. et al. Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network-United States, March-June 2020. Morbidity and Mortality Weekly Report, v. 69, n. 30, p. 993, 2020. https://doi.org/10.15585/mmwr.mm6930e1

TONG, J. Y. et al. The prevalence of olfactory and gustatory dysfunction in COVID-19 patients: a systematic review and meta-analysis. Otolaryngology-Head and Neck Surgery, v. 163, n. 1, p. 3-11, 2020. https://doi.org/10.1177/0194599820926473

UHLIG, K. et al. A framework for crafting clinical practice guidelines that are relevant to the care and management of people with multimorbidity. Journal of General Internal Medicine, v. 29, p. 670-679, 2014. https://doi.org/10.1007/s11606-013-2659-y

VIGILÂNCIA ALIMENTAR E NUTRICIONAL (SISVAN). Orientações básicas para a coleta, processamento, análise de dados e informação em serviços de saúde. 2004. 120 p.

XIE, Y.; BOWE, B.; AL-ALY, Z. Burdens of post-acute sequelae of COVID-19 by severity of acute infection, demographics and health status. Nature communications, v. 12, n. 1, p. 6571, 2021. https://doi.org/10.1038/s41467-021-26513-3

WONG, A. W. et al. Patient-reported outcome measures after COVID-19: a prospective cohort study. European Respiratory Journal, v. 56, n. 5, 2020. https://doi.org/10.1183/13993003.03276-2020

WORLD HEALTH ORGANIZATION. A clinical case definition of post COVID-19 condition by a Delphi consensus: 6 October 2021. Disponível em: https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition Clinical_case_definition-2021.1

WU, Q.; AILSHIRE, J. A.; CRIMMINS, E. M. Long COVID and symptom trajectory in a representative sample of Americans in the first year of the pandemic. Scientific Reports, v. 12, n. 1, jul. 2022. https://doi.org/10.1038/s41598-022-15727-0

YAKSI, N.; TEKER, A. G.; IMRE, A. Long COVID in hospitalized COVID-19 patients: A retrospective cohort study. Iranian Journal of Public Health, v. 51, n. 1, p. 88, 2022.

https://doi.org/10.18502/ijph.v51i1.8297

ZAIM S, CHONG JH, SANKARANARAYANAN V, HARKY A. COVID-19 and Multiorgan Response. Curr Probl Cardiol, v. 45, n. 8:100618, ago. 2020. https://doi.org/10.1016/j.cpcardiol.2020.100618

Downloads

Publicado

23-04-2024

Como Citar

SAES, M. de O.; VIEIRA, Y. P.; ROCHA, J. Q. S.; SILVA, C. N. da; SOARES JUNIOR, A. de O.; NEVES, R. G.; GONÇALVES, C. de S.; DURO, S. M. S. COVID LONGA E FATORES ASSOCIADOS EM INDIVÍDUOS DO SUL DO BRASIL: UM ESTUDO DE BASE POPULACIONAL SULCOVID-19. Hygeia - Revista Brasileira de Geografia Médica e da Saúde, Uberlândia, v. 20, p. e2041, 2024. DOI: 10.14393/Hygeia2070242. Disponível em: https://seer.ufu.br/index.php/hygeia/article/view/70242. Acesso em: 21 dez. 2024.

Edição

Seção

Artigos